Entacapone promotes cAMP‐dependent colonic Cl− secretion in rats
Entacapone promotes cAMP‐dependent colonic Cl− secretion in rats
复制标题
DOI：
10.1111/j.1365-2982.2011.01715.x
复制
发表时间：
2011-07
影响因子：
3.5
通讯作者：
L.‐S. Li;L.‐F. Zheng;J.‐D. Xu;T. Ji;H. Guo;X. Li;Y. Li;Y. Zhang;J-X Zhu
中科院分区：
文献类型：
--
作者：
L.‐S. Li;L.‐F. Zheng;J.‐D. Xu;T. Ji;H. Guo;X. Li;Y. Li;Y. Zhang;J-X Zhu
恩他卡朋作为儿茶酚-O-甲基转移酶（COMT）抑制剂，广泛用于帕金森病（PD）的治疗。然而，恩他卡朋具有胃肠道副作用。本研究旨在观察恩他卡朋对大鼠远端结肠上皮细胞离子转运的影响，并探讨其作用机制。
Background Entacapone is a promising drug used widely for the treatment of Parkinson’s disease (PD) as a catechol‐O‐methyl transferase (COMT) inhibitor. However, entacapone has gastrointestinal side effects. The aim of this study was to investigate the effects of entacapone on the epithelial ion transport in rat distal colon, and explore the underlying mechanism.