Association of a gain-of-function variant in LGR4 with central obesity.
Association of a gain-of-function variant in LGR4 with central obesity.
复制标题
LGR4 的功能获得性变异与中心性肥胖的关联。
DOI：
10.1002/oby.21704
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Wang Jiqiu
中科院分区：
文献类型：
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作者：
Zou Yaoyu;Ning Tinglu;Shi Juan;Chen Maopei;Ding Lin;Huang Ya;Kauderer Sophie;Xu Min;Cui Bin;Bi Yufang;Liu Simin;Hong Jie;Liu Ruixin;Ning Guang;Wang Jiqiu
目的探讨富含亮氨酸重复序列的G蛋白偶联受体4（LGR 4）A750 T（c.2248 G > A）变异与中心性肥胖及相关代谢表型的关系。结果青年组（N =594）LGR 4 A750 T与腰围（P = 0. 030）、腰高比（P <0. 001）相关，社区组（N =1067）LGR 4 A750 T与腰臀比（P = 0. 013）相关。联合分析显示，变异与腰围（P <0.001）和腰臀比（P =0.021）显著相关。此外，变异体与腹部内脏脂肪面积（P =0.004），并与2-h血浆胰岛素（P =0.009）和Matsuda指数（P =0.027）口服葡萄糖耐量试验后，在年轻的肥胖subjects.ConclusionsThe LGR 4 A750 T变异体可能有助于中心性肥胖的特点是腹部内脏脂肪堆积。
ObjectiveTo determine the relationship of the gain‐of‐function variant A750T in leucine‐rich repeat containing G protein‐coupled receptor 4 (LGR4) with central obesity and related metabolic phenotypes.MethodsThe LGR4 A750T (c.2248 G > A) variant was detected by Sanger sequencing in a discovery young population and a validation community‐based population with obesity from eastern China. Fat indices determined by anthropometry and computed tomography scans and clinical biochemical measurements were collected for association analysis.ResultsLGR4 A750T was significantly correlated with waist circumference (P =0.030) and waist‐to‐height ratio (P <0.001) in the young cohort (N =594) and with waist‐to‐hip ratio (P =0.013) in the community population (N =1067). Combined analysis showed a significant correlation of the variant with waist circumference (P <0.001) and waist‐to‐hip ratio (P =0.021). Moreover, the variant had a remarkable correlation with abdominal visceral fat area (P =0.004) and was associated with 2‐h plasma insulin (P =0.009) and the Matsuda index (P =0.027) after an oral glucose tolerance test in young subjects with obesity.ConclusionsThe LGR4 A750T variant may contribute to central obesity characterized by abdominal visceral fat accumulation.