REGIONAL CEREBRAL OXIDATIVE AND TOTAL GLUCOSE CONSUMPTION DURING REST AND ACTIVATION STUDIED WITH POSITRON EMISSION TOMOGRAPHY
REGIONAL CEREBRAL OXIDATIVE AND TOTAL GLUCOSE CONSUMPTION DURING REST AND ACTIVATION STUDIED WITH POSITRON EMISSION TOMOGRAPHY
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DOI：
10.1111/j.1748-1716.1994.tb09718.x
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发表时间：
1994-05-01
期刊：
影响因子：
--
通讯作者：
HAAPARANTA, M
中科院分区：
文献类型：
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作者：
BLOMQVIST, G;SEITZ, RJ;HAAPARANTA, M
用正电子发射断层扫描（PET）研究了5名健康志愿者大脑激活区和非激活区的局部氧化和总rCMR（glc）之间的关系。使用示踪剂[1-C-11]-D-葡萄糖和[2-F-18]2-氟-2-脱氧-D-葡萄糖。先前的研究表明，前者可用于测量葡萄糖氧化的速率，而后者示踪剂用于测量葡萄糖消耗的总速率。进行区域激活（自愿手指运动）。使用计算机化的脑图谱能够比较该组受试者的脑的每个体积元素中的区域氧化和总rCMR（glc）。当计算脑的每个体积元素并显示在散点图中时，发现总和氧化rCMR（glc）的值围绕靠近原点的直线对称地分组。这条线的斜率在受试者之间变化。这表明，无论rCMR（glc）的值如何，平均而言，每个受试者体内的非氧化葡萄糖利用率是恒定的，此外，受试者之间的非氧化葡萄糖利用率不同。（平均值+/-SEM）和11.7+/-0.3%，分别高于对侧同源非活化区。我们对这种差异的解释是，区域激活增加了非氧化葡萄糖消耗的比例。这一解释得到了先前使用[O-15]O-2的PET研究和使用MRS技术的研究的支持。
The relationship between regional oxidative and total rCMR(glc) in five healthy volunteers in activated and non-activated areas of the brain has been investigated with positron emission tomography (PET). The tracers [1-C-11]-D-glucose and [2-F-18]2-fluoro-2-deoxy-D-glucose were used. A previous study has shown that the former may be used to measure the rate of glucose oxidation while the latter tracer is used to measure the total rate of glucose consumption. Regional activation was performed (voluntary finger movements). Use of a computerized brain atlas enabled comparison between the regional oxidative and total rCMR(glc) in each volume element of the brain for the group of subjects.The values of total and oxidative rCMR(glc), when calculated for each volume element of the brain and displayed in a scatter plot, were found to be symmetrically grouped around a straight line which passes close to the origin. The slope of this line varied between the subjects. This indicates that, on the average, the fraction of non-oxidative glucose utilization is constant within each subject, regardless of the value of rCMR(glc) and, further, that the fraction of non-oxidative glucose utilization varies between subjects.The total and oxidative CMR(glc) in the activated left hand area were 23.4+/-0.9% (mean+/-SEM) and 11.7+/-0.3%, respectively, higher than in the contralateral homologous non-activated area. Our interpretation of the difference is that regional activation increases the fraction of non-oxidative glucose consumption. This interpretation is supported by a previous PET study using [O-15]O-2, and by studies using MRS technique.