Loss of CD15 expression in clear cell renal cell carcinoma is correlated with worse prognosis in Chinese patients
Loss of CD15 expression in clear cell renal cell carcinoma is correlated with worse prognosis in Chinese patients
复制标题
透明细胞肾细胞癌中 CD15 表达缺失与中国患者预后较差相关
DOI：
10.1093/jjco/hyx139
复制
发表时间：
2017
影响因子：
2.4
通讯作者：
Yun Cao
中科院分区：
文献类型：
--
作者：
Chen;Jianping Huo;Xinke Zhang;Yi;Wan;Ping Yang;Jia;Zhiling Zhang;Yun Cao
目的
目的探讨CD 15表达与肾透明细胞癌（ccRCC）预后的关系。
方法
该研究包括301名接受局部ccRCC手术的患者。收集所有石蜡包埋的肿瘤切片以制作一组组织微阵列。免疫组化法检测CD 15表达。分析CD 15表达与生存参数、临床病理特征的关系。采用Kaplan-Meier和考克斯比例风险模型分析CD 15表达与总生存期（OS）的相关性。
结果
中位随访时间为54.6个月（范围：3-121个月）。CD 15阳性表达率为81.7%（246/301）。通过绘制生存状态的受试者工作特征曲线，将CD 15表达的临界值定义为Youden指数的最大值。以0.5为阈值，将所有病例分为两组：阳性表达组和阴性表达组。相关性分析显示，CD 15表达缺失与女性、较高的Fuhrman核分级、肉瘤样分化、坏死和血管浸润相关。Kaplan-Meier分析显示CD 15表达缺失的患者OS时间短于CD 15表达阳性的患者（P = 0.013）。
结论
CD 15是肾透明细胞癌的重要预后因子。
Purpose
To explore the role of CD15 expression in the prognosis of clear cell renal cell carcinoma (ccRCC) in Chinese patients.
Methods
The study included 301 patients who had undergone surgery for localized ccRCC. All paraffin-embedded tumor sections were collected to make a set of tissue microarrays. CD15 expression was assessed by immunohistochemistry. The relationship between CD15 expression and survival parameters, clinicopathology features was assessed. Kaplan-Meier and Cox proportional hazards model were utilized to determine the correlation between CD15 expression and overall survival (OS).
Results
The median follow-up time was 54.6 months (range, 3-121 months). The positive rate of CD15 expression was 81.7% (246/301). The cut-off value of CD15 expression was defined as the maximum for Youden index by plotting the receiver operating characteristic curve for survival status. As the threshold was 0.5, all cases were divided into two groups: positive expression group and negative expression group. In correlation analysis, loss of CD15 expression was correlated with female gender, higher Fuhrman nuclear grade, with sarcomatoid differentiation, with necrosis, and with vascular invasion. Kaplan-Meier analysis indicated that the OS time of patients with loss of CD15 expression was shorter than that of patients with positive CD15 expression (P = 0.013).
Conclusion
CD15 is a significant prognostic factor in clear cell renal cell carcinoma.
影响因子：
4.4
作者：
Zhao, Jia;Patwa, Tasneem H.;Lubman, David M.
通讯作者：
Lubman, David M.
影响因子：
50.3
作者：
Read TA;Fogarty MP;Markant SL;McLendon RE;Wei Z;Ellison DW;Febbo PG;Wechsler-Reya RJ
通讯作者：
Wechsler-Reya RJ
影响因子：
20.3
作者：
Lo, SK;Golenbock, DT;Silverstein, RL
通讯作者：
Silverstein, RL