The effects of callous-unemotional traits and aggression subtypes on amygdala activity in response to negative faces
The effects of callous-unemotional traits and aggression subtypes on amygdala activity in response to negative faces
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DOI：
10.1017/s0033291720002111
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发表时间：
2022-02-01
影响因子：
6.9
通讯作者：
Brandeis, Daniel
中科院分区：
文献类型：
--
作者：
Aggensteiner, Pascal-M;Holz, Nathalie E.;Brandeis, Daniel
背景脑成像研究显示，与正常发育的儿童和青少年（TD）相比，对立违抗性障碍（ODD）和品行障碍（CD）儿童和青少年在情绪处理过程中杏仁核活动发生了改变。在这里，我们的目的是评估是否侵略相关的亚型（反应性和积极主动的侵略）和冷酷无情（CU）的特质预测杏仁核活动和皮肤电导（SC）的变化在情绪处理过程中的反应。方法我们纳入了177名参与者（n = 108例破坏性行为和/或ODD/CD和n = 69 TD），年龄8-18岁，在欧洲的9个地点，作为欧盟Aggressotype和MATRICS项目的一部分。所有参与者进行了情感面部匹配功能磁共振成像任务。结果评估了病例和TD在情感加工方面的差异，以及攻击亚型和CU特质激活模式的特异性。在子样本（n = 63）中采集了同时SC记录。与TD相比，病例在对负面面孔（恐惧和愤怒）和形状的反应中表现出更高的杏仁核活性。根据攻击相关亚型的亚型病例没有显着影响杏仁核的活动，而分层的基础上CU性状更敏感，揭示了降低杏仁核的活动在高CU组。SC反应显着降低的情况下，与CU性状，反应性和主动攻击呈负相关。结论ODD/CD和TD患者对情绪面孔的杏仁核活动和SC反应存在差异，而CU特质调节中枢（杏仁核）和外周（SC）反应。我们关于亚型和特质特异性攻击的见解可用于改进诊断和个性化治疗。
Background Brain imaging studies have shown altered amygdala activity during emotion processing in children and adolescents with oppositional defiant disorder (ODD) and conduct disorder (CD) compared to typically developing children and adolescents (TD). Here we aimed to assess whether aggression-related subtypes (reactive and proactive aggression) and callous-unemotional (CU) traits predicted variation in amygdala activity and skin conductance (SC) response during emotion processing. Methods We included 177 participants (n = 108 cases with disruptive behaviour and/or ODD/CD and n = 69 TD), aged 8-18 years, across nine sites in Europe, as part of the EU Aggressotype and MATRICS projects. All participants performed an emotional face-matching functional magnetic resonance imaging task. Results Differences between cases and TD in affective processing, as well as specificity of activation patterns for aggression subtypes and CU traits, were assessed. Simultaneous SC recordings were acquired in a subsample (n = 63). Cases compared to TDs showed higher amygdala activity in response to negative faces (fearful and angry) v. shapes. Subtyping cases according to aggression-related subtypes did not significantly influence on amygdala activity; while stratification based on CU traits was more sensitive and revealed decreased amygdala activity in the high CU group. SC responses were significantly lower in cases and negatively correlated with CU traits, reactive and proactive aggression. Conclusions Our results showed differences in amygdala activity and SC responses to emotional faces between cases with ODD/CD and TD, while CU traits moderate both central (amygdala) and peripheral (SC) responses. Our insights regarding subtypes and trait-specific aggression could be used for improved diagnostics and personalized treatment.