Antibiotic-Induced Changes in the Intestinal Microbiota and Disease.
Antibiotic-Induced Changes in the Intestinal Microbiota and Disease.
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DOI：
10.1016/j.molmed.2016.04.003
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发表时间：
2016-06
影响因子：
13.6
通讯作者：
Pamer EG
中科院分区：
文献类型：
--
作者：
Becattini S;Taur Y;Pamer EG
肠道微生物区系在人类的许多生理和病理过程中起着关键作用。最近的研究表明，一些临床方法的疗效取决于共生细菌的作用。抗生素是对抗传染病的宝贵武器。然而，通过改变微生物区系的组成和功能，它们也可以对宿主产生长期的有害影响。耐多药病原体的出现引起了人们对常见的、有时不适当的抗菌剂使用的担忧。在这里，我们回顾了最近发现的宿主病理生理学、微生物区系和抗生素之间的联系，重点介绍了通过保留微生物区系的有益功能来增强疾病抵抗力的技术平台、机械见解和临床策略。
The gut microbiota is a key player in many physiological and pathological processes occurring in humans. Recent investigations suggest that the efficacy of some clinical approaches depends on the action of commensal bacteria. Antibiotics are invaluable weapons to fight infectious diseases. However, by altering the composition and functions of the microbiota, they can also produce long-lasting deleterious effects for the host. The emergence of multidrug-resistant pathogens raises concerns about the common, and at times inappropriate, use of antimicrobial agents. Here we review the most recently discovered connections between host pathophysiology, microbiota, and antibiotics highlighting technological platforms, mechanistic insights, and clinical strategies to enhance resistance to diseases by preserving the beneficial functions of the microbiota.