Responses evoked by electrical stimulation of the brainstem reticular formation in the jaw-opening and hypoglossal motor nerves of an arterially perfused rat preparation
Responses evoked by electrical stimulation of the brainstem reticular formation in the jaw-opening and hypoglossal motor nerves of an arterially perfused rat preparation
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DOI：
10.1016/j.neulet.2020.135400
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发表时间：
2020-11-01
影响因子：
2.5
通讯作者：
Inoue，Tomio
中科院分区：
文献类型：
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作者：
Ofuji，Takuo;Nakayama，Kiyomi;Inoue，Tomio
脑干网状结构中的中间神经元系统在各种口面部运动行为期间的精细肌肉协调中发挥着重要作用。在这项研究中，我们使用动脉灌注的大鼠制剂检查了脑干网状结构中诱导下颌舌骨（张口）和舌下神经单突触运动活动的部位的分布。对脑干 309 个部位中的 286 个和 247 个部位施加电刺激，分别诱发下颌舌骨神经和舌下神经的神经活动。下颌舌骨神经反应第一成分的平均潜伏期明显短于舌下神经反应。此外，舌下神经反应中第一个分量的潜伏期直方图是双峰的，其间隔为 4.0 ms。下颌舌骨神经和舌下神经诱导短潜伏期（<4.0 ms）运动活动的部位通常分别分布在脑干网状结构的头侧部分和尾侧部分。下颌舌骨和舌下神经反应的短潜伏期位点分布的这种差异可能对应于针对下颌舌骨和舌下运动神经元的兴奋性前运动神经元的分布。
The interneuronal system in the brainstem reticular formation plays an important role in elaborate muscle coordination during various orofacial motor behaviors. In this study, we examined the distribution in the brainstem reticular formation of the sites that induce monosynaptic motor activity in the mylohyoid (jaw-opening) and hypoglossal nerves using an arterially perfused rat preparation. Electrical stimulation applied to 286 and 247 of the 309 sites in the brainstem evoked neural activity in the mylohyoid and hypoglossal nerves, respectively. The mean latency of the first component in the mylohyoid nerve response was significantly shorter than that in the hypoglossal nerve response. Moreover, the latency histogram of the first component in the hypoglossal nerve responses was bimodal, which was separated by 4.0 ms. The sites that induced short-latency (<4.0 ms) motor activity in the mylohyoid nerve and the hypoglossal nerve were frequently distributed in the rostral portion and the caudal portion of the brainstem reticular formation, respectively. Such difference in distributions of short-latency sites for mylohyoid and hypoglossal nerve responses likely corresponds to the distribution of excitatory premotor neurons targeting mylohyoid and hypoglossal motoneurons.