Days out of role and somatic, anxious-depressive, hypo-manic, and psychotic-like symptom dimensions in a community sample of young adults.
Days out of role and somatic, anxious-depressive, hypo-manic, and psychotic-like symptom dimensions in a community sample of young adults.
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DOI：
10.1038/s41398-021-01390-y
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发表时间：
2021-05-13
影响因子：
6.8
通讯作者：
Hickie IB
中科院分区：
文献类型：
--
作者：
Crouse JJ;Ho N;Scott J;Martin NG;Couvy-Duchesne B;Hermens DF;Parker R;Gillespie NA;Medland SE;Hickie IB
提高我们对青年人功能障碍原因的认识是一项重大的全球挑战。在这里，我们调查了在一个以社区为基础的年轻人队列中，自我报告的角色外的天数与自我报告的躯体、焦虑抑郁、精神病样和轻躁狂症状的总量和不同模式之间的关系。我们检查了参与布里斯班纵向双胞胎研究的“19 Up”波的>1900名年轻成年双胞胎和非双胞胎兄弟姐妹的23种症状的自我评定，这些症状的范围包括四个维度和角色的天数。校正后的患病率（APR）和95%置信区间（95%CI）量化了损伤和不同症状模式之间的关联。三个单独的症状表现出显着的协会与天的作用，最大的协会受损的浓度。当根据每个症状维度评估损害时，躯体症状总数与损害可能性之间存在明显的逐步关系，而报告≥4个焦虑抑郁症状或5个轻躁狂症状的个体报告脱离角色天数的可能性更大。此外，未分化症状的总数与报告脱离角色天数的可能性之间存在逐步关系。当队列按性别分层时，但不按年龄或双胞胎状态分层时，在关联的程度和意义上存在一些差异。我们的研究结果加强了早期干预心理健康框架的发展，如果得到证实，支持需要考虑对阈值以下和/或未分化综合征进行干预，以减少年轻人的残疾。
Improving our understanding of the causes of functional impairment in young people is a major global challenge. Here, we investigated the relationships between self-reported days out of role and the total quantity and different patterns of self-reported somatic, anxious-depressive, psychotic-like, and hypomanic symptoms in a community-based cohort of young adults. We examined self-ratings of 23 symptoms ranging across the four dimensions and days out of role in >1900 young adult twins and non-twin siblings participating in the “19Up” wave of the Brisbane Longitudinal Twin Study. Adjusted prevalence ratios (APR) and 95% confidence intervals (95% CI) quantified associations between impairment and different symptom patterns. Three individual symptoms showed significant associations with days out of role, with the largest association for impaired concentration. When impairment was assessed according to each symptom dimension, there was a clear stepwise relationship between the total number of somatic symptoms and the likelihood of impairment, while individuals reporting ≥4 anxious-depressive symptoms or five hypomanic symptoms had greater likelihood of reporting days out of role. Furthermore, there was a stepwise relationship between the total number of undifferentiated symptoms and the likelihood of reporting days out of role. There was some suggestion of differences in the magnitude and significance of associations when the cohort was stratified according to sex, but not for age or twin status. Our findings reinforce the development of early intervention mental health frameworks and, if confirmed, support the need to consider interventions for subthreshold and/or undifferentiated syndromes for reducing disability among young people.
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DOI：
10.1016/s2215-0366(17)30328-0
发表时间：
2017-10
期刊：
The lancet. Psychiatry
影响因子：
--
作者：
Freeman D;Sheaves B;Goodwin GM;Yu LM;Nickless A;Harrison PJ;Emsley R;Luik AI;Foster RG;Wadekar V;Hinds C;Gumley A;Jones R;Lightman S;Jones S;Bentall R;Kinderman P;Rowse G;Brugha T;Blagrove M;Gregory AM;Fleming L;Walklet E;Glazebrook C;Davies EB;Hollis C;Haddock G;John B;Coulson M;Fowler D;Pugh K;Cape J;Moseley P;Brown G;Hughes C;Obonsawin M;Coker S;Watkins E;Schwannauer M;MacMahon K;Siriwardena AN;Espie CA
通讯作者：
Espie CA
影响因子：
5.4
作者：
Bechdolf, Andreas;Ratheesh, Aswin;McGorry, Patrick D.
通讯作者：
McGorry, Patrick D.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
6.9
作者：
GOLDBERG, DP;HILLIER, VF
通讯作者：
HILLIER, VF
影响因子：
6.6
作者：
Angst, J;Gamma, A;Rössler, W
通讯作者：
Rössler, W