New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium)
New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium)
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DOI：
10.1016/j.bmcl.2007.06.027
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发表时间：
2007-09-01
影响因子：
2.7
通讯作者：
Yoshikawa, Masayuki
中科院分区：
文献类型：
--
作者：
Zhang, Hailong;Matsuda, Hisashi;Yoshikawa, Masayuki
从绣球花叶中分离得到2个3-苯基二氢异香豆素(绣球烯醇和叶黄素)、1个3-苯基异香豆素(叔丁基醇A)和1个二苯乙烯(绣球花酸)。玄参可促进3T3-L1细胞的成脂作用。主要成分Hydrangenol显著增加脂联素的释放量和脂联素、PPAR-激活受体72(PPAR-Gamma-2)和葡萄糖转运蛋白4(GLUT4)的mRNA水平，同时降低IL-6mRNA的表达。此外，在KK-A(Y)小鼠服用200 mg/kg/d剂量2周后，绣球烯醇显著降低血糖和游离脂肪酸水平。(C)2007爱思唯尔有限公司。保留所有权利。
Two 3-phenyldihydroisocoumarins (hydrangenol and phyllodulcin), a 3-phenylisocoumarin (thunberginol A), and a stilbene (hydrangeaic acid) from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium) promoted adipogenesis of 3T3-L1 cells. Hydrangenol, a principal constituent, significantly increased the amount of adiponectin released into the medium and mRNA levels of adiponectin, peroxisome proliferator-activated receptor 72 (PPAR gamma 2), and glucose transporter 4 (GLUT4), while it decreased the expression of interleukin 6 (IL-6) mRNA. Furthermore, hydrangenol significantly lowered blood glucose and free fatty acid levels 2 weeks after its administration at a dose of 200 mg/kg/d in KK-A(y) mice. (C) 2007 Elsevier Ltd. All rights reserved.