Gender differences in language of AD patients
Gender differences in language of AD patients
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DOI：
10.1212/wnl.45.2.299
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发表时间：
1995-02
期刊：
影响因子：
9.9
通讯作者：
D. Ripich;S. Petrill;P. Whitehouse;Elaine W. Ziol
中科院分区：
文献类型：
--
作者：
D. Ripich;S. Petrill;P. Whitehouse;Elaine W. Ziol
文章摘要-我们检查了可能的阿尔茨海默病（AD）患者在四个数据收集（入组，6，12和18个月）和正常老年人（NE）对照组在入组和18个月的语言测量的性别差异。比较60名（29名男性，31名女性）早期（临床痴呆评分I和11）AD受试者在入学时语言能力的性别差异，发现性别对波士顿词汇测试（BNT）和皮博迪图片词汇测试修订版（PPVT-R）有显著影响，但对单词流畅性测试、缩短标记测试或修改后的记者测试无显著影响。37名受试者（18名男性，19名女性）谁完成了不到四个数据收集会议相比，23名受试者（11名男性，12名女性）谁完成了所有四个会议不同的教育和记者的测试成绩。措施的纵向分析表明，性别差异持续存在的BNT和PPVT-R和时间差异，发现所有措施。在校正了年龄、教育程度、患病时间和精神状态后，性别差异仍然存在。我们发现NE对照组在性别或时间方面没有差异。所有AD受试者的趋势都是下降的，这表明（1）随着时间的推移，AD的语言受到影响，（2）男性和女性的下降速度相似，（3）女性的语言能力在所有时间点都受到更严重的损害。
Article abstract—We examined gender differences in probable Alzheimer's disease (AD) patients on language measures at four data collections (entry, 6, 12, and 18 months) and a normal elderly (NE) comparison group at entry and 18 months. Comparison of gender differences in language abilities of 60 (29 men, 31 women) early (Clinical Dementia Ratings I and 11) AD subjects at entry revealed significant effects for gender on the Boston Naming Test (BNT) and Peabody Picture Vocabulary Test-Revised (PPVT-R) but not on the Word Fluency Test, shortened Token Test, or modified Reporter's Test. The 37 subjects (18 men, 19 women) who completed less than four data collection sessions compared with the 23 subjects (11 men, 12 women) who completed all four sessions differed on education and Reporter's Test scores. Longitudinal analysis of measures showed that gender differences persisted for the BNT and PPVT-R and that time differences were found on all measures. Gender differences remained after correcting for age, education, duration of illness, and mental status. We found no differences for the NE comparison group for gender or time. All AD subject trends were downward, suggesting that (1) language is affected over time in AD, (2) both men and women decline at similar rates, and (3) language abilities of women are more severely impaired at all time points.