Peptide YY: metabolism and effect on pancreatic secretion in dogs.
Peptide YY: metabolism and effect on pancreatic secretion in dogs.
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肽YY：狗的代谢及其对胰腺分泌的影响。
DOI：
10.1016/0016-5085(85)90659-6
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发表时间：
1985
期刊：
影响因子：
29.4
通讯作者：
Taylor,IL
中科院分区：
文献类型：
--
作者：
Pappas,TN;Debas,HT;Taylor,IL
肽YY是一种回结肠肽，当以400 pmol/kg · h的剂量输注时，可抑制餐后刺激的胰腺分泌。在这项研究中，在同时输注生理盐水或肽YY（400 pmol/kg · h）期间，监测胰泌素或八肽胆囊收缩素（62.5、125、250和500 ng/kg ·h）对胰腺分泌的反应。YY肽显著（p < 0.05）抑制对三种最低剂量促胰泌素的分泌反应，使对62.5ng/kg · h促胰泌素的碳酸氢盐反应降低86% ± 6%，使对相同剂量胆囊收缩素的蛋白反应降低57% ± 16%。在研究的第二分支中，发现肽YY的半衰期（11.7 ± 21 min）和代谢清除率（13.8 ± 1.6 ml/kg · min）与其他胃肠激素相似。我们的结论是，抑制膳食刺激的胰腺分泌肽YY可以解释其能力，降低胰腺内源性促分泌素的反应。
Peptide YY is an ileocolonic peptide that inhibits meal-stimulated pancreatic secretion when infused in a dose of 400 pmol/kg · h. In this study pancreatic secretion was monitored in response to increasing doses of secretin or cholecystokinin-octapeptide (62.5, 125, 250, and 500 ng/kg · h) during the simultaneous infusion of either saline or peptide YY (400 pmol/kg · h). Peptide YY significantly (p < 0.05) inhibited the secretory response to the three lowest doses of each pancreatic secretogogue, reducing the bicarbonate response to the 62.5-ng/kg · h dose of secretin by 86% ± 6% and the protein response to the same dose of cholecystokinin by 57% ± 16%. In the second limb of the study, the half-life of peptide YY (11.7 ± 21 min) and the metabolic clearance rate (13.8 ± 1.6 ml/kg · min) were found to be similar to those of other gastrointestinal hormones. We conclude that inhibition of meal-stimulated pancreatic secretion by peptide YY can be explained by its ability to decrease the responsiveness of the pancreas to endogenous secretogogues.