Iron-catalyzed direct arylation through directed C-H bond activation
Iron-catalyzed direct arylation through directed C-H bond activation
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DOI：
10.1021/ja800818b
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发表时间：
2008-05-07
影响因子：
15
通讯作者：
Nakamura, Eiichi
中科院分区：
文献类型：
--
作者：
Norinder, Jakob;Matsumoto, Arimasa;Nakamura, Eiichi
一种铁催化的含氮芳族化合物与芳基锌试剂的C-C键形成反应在0 ℃下以良好的定量产率发生。该反应涉及由相邻氮原子引导的C-H键活化。该反应中的重要添加剂是1，10-菲咯啉、四甲基乙二胺和1，2-二氯-2-甲基丙烷，在没有它们的情况下观察到非常低的产物产率。
An iron-catalyzed C-C bond formation reaction of a nitrogencontaining aromatic compound with an arylzinc reagent takes place at 0 degrees C in a good to quantitative yield. The reaction involves a C-H bond activation directed by a neighboring nitrogen atom. The important additives in this reaction are 1,10-phenanthroline, tetramethylethylenediamine, and 1,2-dichloro2-methylpropane, in the absence of which a very low product yield was observed.