Increased tumor control rates in murine fibrosarcoma by combined therapy with L-alanosine and radiation.
Increased tumor control rates in murine fibrosarcoma by combined therapy with L-alanosine and radiation.
复制标题
L-丙氨酸和放射联合治疗可提高小鼠纤维肉瘤的肿瘤控制率。
DOI：
10.1111/j.1349-7006.1989.tb01680.x
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Kim,JH
中科院分区：
文献类型：
--
作者：
Hong,SS;Alfieri,AA;Kim,SH;Kim,JH
L丙氨酸是L天冬氨酸的类似物，被认为是一系列化合物之一，可能对辐射所致的潜在致命性损伤的修复具有抑制作用。L-丙氨酸单次给药(600 mg/kg)和X射线单次照射(20Gy)联合治疗，肿瘤控制率为62%，而单纯放射治疗的肿瘤控制率不到5%。在X射线照射前8h给药，L-丙氨酸氨基葡萄糖苷的增强作用更强。该药物对Meth-A肿瘤的剂量修正系数估计为1.4。联合应用丙氨酸氨基葡萄糖苷和放射治疗的肿瘤控制率的提高高度依赖于联合治疗的时间和顺序。X-射线照射前8小时内疗效降低的原因似乎部分与L-丙氨酸氯胺酮合用时对体温的调节有关。
L‐Alanosine, an analog of L‐aspartie acid, was investigated as one of a series of chemical compounds that may have inhibitory effects on the repair of potentially lethal damage caused by radiation using anin vivomurine fibrosarcoma (Meth‐A tumor) in BALB/cBy male mice. The combined treatment of single administration of L‐alanosine (600 mg/kg) and single dose of X‐irradiation (20 Gy) on Meth‐A tumors produced 62% tumor control, while the radiation alone resulted in less than 5% tumor control. The potentiating effect by L‐alanosine was higher when the drug was administered 8 h prior to X‐irradiation. The dose modification factor of the drug is estimated to be 1.4 for Meth‐A tumor. The increased tumor control rates with combined alanosine and radiation were highly dependent upon the time and sequence of the combined treatment. The reason for reduced efficacy at treatment times of less than 8 h prior to X‐irradiations appears to be related in part to the modulation of the body temperature by L‐alanosine when combined with Ketamine, an anesthetic agent.