Pioglitazone activates paraoxonase-2 in the brain: A novel neuroprotective mechanism
Pioglitazone activates paraoxonase-2 in the brain: A novel neuroprotective mechanism
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DOI：
10.1016/j.expneurol.2020.113234
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发表时间：
2020-05-01
影响因子：
5.3
通讯作者：
Elsworth, John D.
中科院分区：
文献类型：
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作者：
Blackburn, Jennifer K.;Curry, Daniel W.;Elsworth, John D.
对氧磷酶-2调节线粒体中活性氧的产生。刺激其表达对氧化应激在病理中起重要作用的疾病具有治疗潜力。有证据表明，抗糖尿病药物吡格列酮可能对帕金森病、阿尔茨海默病、脑损伤和缺血提供神经保护，但其生化途径尚未完全阐明。本研究报告吡格列酮（10 mg/kg/天）5天显著增加小鼠纹状体对氧磷酶-2的表达。因此，该结果突出了对氧磷酶-2作为神经保护策略的靶点，并确定吡格列酮作为研究对氧磷酶-2在脑中的作用的工具。
Paraoxonase-2 regulates reactive oxygen species production in mitochondria. Stimulating its expression has therapeutic potential for diseases where oxidative stress plays a significant role in the pathology. Evidence suggests that the anti-diabetic drug pioglitazone may provide neuroprotection in Parkinson's disease, Alzheimer's disease, brain trauma and ischemia, but the biochemical pathway(s) responsible has not been fully elucidated. Here we report that pioglitazone (10 mg/kg/day) for 5 days significantly increased paraoxonase-2 expression in mouse striatum. Thus, this result highlights paraoxonase-2 as a target for neuroprotective strategies and identifies pioglitazone as a tool to study the role of paraoxonase-2 in brain.