ABSOLUTE PERIPHERAL-BLOOD LYMPHOCYTE COUNT AND SUBSEQUENT MORTALITY OF ELDERLY MEN - THE BALTIMORE LONGITUDINAL-STUDY OF AGING
ABSOLUTE PERIPHERAL-BLOOD LYMPHOCYTE COUNT AND SUBSEQUENT MORTALITY OF ELDERLY MEN - THE BALTIMORE LONGITUDINAL-STUDY OF AGING
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DOI：
10.1111/j.1532-5415.1986.tb04906.x
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发表时间：
1986-09-01
影响因子：
6.3
通讯作者：
ANDRES, R
中科院分区：
文献类型：
--
作者：
BENDER, BS;NAGEL, JE;ANDRES, R
在这项对105名健康老年男性进行的长达16年的纵向研究中，我们分析了免疫衰老的一个方面，即外周血淋巴细胞绝对数量的下降，特别是其与随后死亡率的关系。发现淋巴细胞绝对计数显著（P <0.01）降低（1432 ± 0.01）。55/mm 3，平均值±。SEM）在三年内死亡时相比，五年（1719 .+-。89/mm 3）或10年（1715 . ±. 98/mm3）。淋巴细胞减少与死亡年龄、吸烟状况或既往心脏病之间没有关系。以前的横断面研究得出了与年龄相关的淋巴细胞减少的相互矛盾的数据，这可能是一个未被认识到的选择过程的结果，该过程排除或包括接近死亡的受试者。
In this 16-year longitudinal study of 105 healthy elderly men, we analyzed one aspect of immunosenescence.sbd.a decline in the absolute number of peripheral blood lymphocytes.sbd.with particular reference to its relationship with subsequent mortality. It was found that there was a significantly (P < .01) lower absolute lymphocyte count (1432 .+-. 55/mm3, mean .+-. SEM) within three years of death when compared with five years (1719 .+-. 89/mm3) or 10 years (1715 .+-. 98/mm3) before death. There was no relationship between this decrease in lymphocytes and age at death, smoking status, or prior cardiac illness. Previous cross-sectional studies have yielded conflicting data on age-related decreases in lymphocytes which may have been the result of an unrecognized selection process that either eliminated or included subjects who were close to death.