Prospects for organ and tissue replacement.
Prospects for organ and tissue replacement.
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DOI：
10.1001/jama.285.5.573
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发表时间：
2001-02
期刊：
影响因子：
--
通讯作者：
Laura E. Niklason;Robert Langer
中科院分区：
文献类型：
--
作者：
Laura E. Niklason;Robert Langer
组织或器官的损坏或丢失是常见的、代价高昂的和悲惨的。机械人造器官和器官移植的进展改善了器官衰竭的治疗，分子免疫学、组织工程学和干细胞生物学的进步为未来治疗器官衰竭提供了更好的治疗方式。移植组织免疫耐受性的提高、对细胞分化和组织发育认识的加深以及生物材料的进步可能使移植组织和器官的从头创造成为可能。预防和治疗组织丢失和器官衰竭的创新技术应该会提高生命质量和寿命。
Damage or loss of a tissue or organ is common, costly, and tragic. Advances in mechanical artificial organs and organ transplantation have improved the treatment of organ failure, and advances in molecular immunology, tissue engineering, and stem cell biology offer the promise of even better therapeutic modalities for treating organ failure in the future. Enhancement of immune tolerance of transplanted tissues, improved understanding of cellular differentiation and tissue development, and advances in biomaterials may enable the de novo creation of implantable tissue and organs for transplantation. Innovative techniques for prevention and treatment of tissue loss and organ failure should improve the quality and length of life.