Prostate cancer measurements on serial MRI during active surveillance: it's time to be PRECISE
Prostate cancer measurements on serial MRI during active surveillance: it's time to be PRECISE
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DOI：
10.1259/bjr.20200819
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发表时间：
2020-01-01
影响因子：
2.6
通讯作者：
Moore, Caroline M.
中科院分区：
文献类型：
--
作者：
Giganti, Francesco;Stavrinides, Vasilis;Moore, Caroline M.
目的：在前列腺癌（PCa）主动监测（AS）患者中报告多参数MRI的PRECISE标准使用1-5量表对随时间推移发生临床显著变化的可能性进行评分，其中4或5表示放射学进展。根据PRECISE建议，可以使用不同的体积定义（测面积法或椭圆体公式）或通过测量一个或两个直径来报告索引病变大小。我们比较了不同的测量使用面积作为参考标准和分层变化根据PRECISE scores.Methods：我们回顾性分析了196例AS与PCa有两个MR扫描（基线和后续）的靶向活检证实。根据所有定义，在T2加权成像（T2 WI）上测量病灶。对每位患者进行PRECISE评分。椭球体公式与基线测面法的相关性最高（rho = 0.97）和随访（ρ = 0.98）成像，与双轴测量和单个最大直径相比，有显著性差异（p < 0.001）放射学回归/稳定之间的年体积变化百分比结论：椭圆体公式可用于AS时肿瘤生长的监测。也观察到放射学回归/稳定性（PRECISE 2-3）和进展（PRECISE 4-5）之间显著的年度体积百分比变化的证据：在成像引导的AS患者中，在T2 WI上捕获肿瘤体积变化时，椭球体公式是平面测量的合理替代品。这也与使用PRECISE建议的放射学变化相关。
Objective: The PRECISE criteria for reporting multiparametric MRI in patients on active surveillance (AS) for prostate cancer (PCa) score the likelihood of clinically significant change over time using a 1-5 scale, where 4 or 5 indicates radiological progression. According to the PRECISE recommendations, the index lesion size can be reported using different definitions of volume (planimetry or ellipsoid formula) or by measuring one or two diameters. We compared different measurements using planimetry as the reference standard and stratified changes according to the PRECISE scores.Methods: We retrospectively analysed 196 patients on AS with PCa confirmed by targeted biopsy who had two MR scans (baseline and follow-up). Lesions were measured on T-2 weighted imaging (T2WI) according to all definitions. A PRECISE score was assessed for each patient.Results: The ellipsoid formula exhibited the highest correlation with planimetry at baseline (rho = 0.97) and follow-up (rho = 0.98) imaging, compared to the biaxial measurement and single maximum diameter, There was a significant difference (p < 0.001) in the yearly percentage volume change between radiological regression/stability (PRECISE 2-3) and progression (PRECISE 4-5) for planimetry (39.64%) and for the ellipsoid formula (46.78%).Conclusion: The ellipsoid formula could be used to monitor tumour growth during AS. Evidence of a significant yearly percentage volume change between radiological regression/stability (PRECISE 2-3) and progression (PRECISE 4-5) has been also observed.Advances in knowledge: The ellipsoid formula is a reasonable surrogate for planimetry in capturing tumour volume changes on T2WI in patients on imaging-led AS. This is also associated with radiological changes using the PRECISE recommendations.