The impact of parkinson's disease on the cortical mechanisms that support auditory-motor integration for voice control
The impact of parkinson's disease on the cortical mechanisms that support auditory-motor integration for voice control
复制标题
帕金森病对支持听觉运动整合以进行语音控制的皮质机制的影响
DOI：
10.1002/hbm.23306
复制
发表时间：
2016-12-01
影响因子：
4.8
通讯作者：
Liu, Hanjun
中科院分区：
文献类型：
--
作者：
Huang, Xiyan;Chen, Xi;Liu, Hanjun
多项研究表明，特发性帕金森病 (PD) 患者在言语处理方面存在感觉运动缺陷。然而，人们对潜在的神经机制仍然知之甚少。在目前的事件相关电位 (ERP) 研究中，18 名帕金森病患者和 18 名健康对照者在发出持续元音并聆听自己声音的回放时接受频率改变反馈 (FAF)。行为结果显示，与健康对照组相比，帕金森病患者对音调反馈误差产生了明显更大的声音补偿，并且在他们的声音反应幅度和未改变的音调变化之间表现出显着的正相关。在皮质水平上，由于额上回和额下回、运动前皮层、顶下小叶和颞上回的左偏活动增强，与健康对照相比，PD 个体在主动发声期间观察到更大的 P2 反应。然而，当这两组人被动地聆听自己声音的播放时，他们并没有什么不同。与被动聆听相比，PD 患者在主动发声时也表现出更大的 P2 反应，因为额下回、中央前回、中央后回和颞中回的活动增强。然而，在健康对照中没有观察到这种增强效果。这些发现为帕金森病患者声音控制的听觉-声音整合异常提供了神经证据，这可能是由于他们在检测和纠正声音听觉反馈错误方面的缺陷造成的。 Hum Brain Mapp 37:4248-4261, 2016。(c) 2016 Wiley periodicals, Inc.
Several studies have shown sensorimotor deficits in speech processing in individuals with idiopathic Parkinson's disease (PD). The underlying neural mechanisms, however, remain poorly understood. In the present event-related potential (ERP) study, 18 individuals with PD and 18 healthy controls were exposed to frequency-altered feedback (FAF) while producing a sustained vowel and listening to the playback of their own voice. Behavioral results revealed that individuals with PD produced significantly larger vocal compensation for pitch feedback errors than healthy controls, and exhibited a significant positive correlation between the magnitude of their vocal responses and the variability of their unaltered vocal pitch. At the cortical level, larger P2 responses were observed for individuals with PD compared with healthy controls during active vocalization due to left-lateralized enhanced activity in the superior and inferior frontal gyrus, premotor cortex, inferior parietal lobule, and superior temporal gyrus. These two groups did not differ, however, when they passively listened to the playback of their own voice. Individuals with PD also exhibited larger P2 responses during active vocalization when compared with passive listening due to enhanced activity in the inferior frontal gyrus, precental gyrus, postcentral gyrus, and middle temporal gyrus. This enhancement effect, however, was not observed for healthy controls. These findings provide neural evidence for the abnormal auditory-vocal integration for voice control in individuals with PD, which may be caused by their deficits in the detection and correction of errors in voice auditory feedback. Hum Brain Mapp 37:4248-4261, 2016. (c) 2016 Wiley Periodicals, Inc.