Adjusting Haemoglobin Values for Altitude Maximizes Combined Sensitivity and Specificity to Detect Iron Deficiency among Women of Reproductive Age in Johannesburg, South Africa
Adjusting Haemoglobin Values for Altitude Maximizes Combined Sensitivity and Specificity to Detect Iron Deficiency among Women of Reproductive Age in Johannesburg, South Africa
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DOI：
10.3390/nu12030633
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发表时间：
2020-03-01
期刊：
影响因子：
5.9
通讯作者：
Norris, Shane
中科院分区：
文献类型：
--
作者：
Silubonde, Takana Mary;Baumgartner, Jeannine;Norris, Shane
在南非，测量血红蛋白（Hb）以筛查缺铁（ID）。然而，低水平的Hb只是ID的晚期指标。此外，Hb值通常不调整海拔高度，即使世界卫生组织建议。我们确定了血红蛋白阈值与最高的综合灵敏度和特异性检测ID生活在海拔1700米以上的南非妇女。在对492名18-25岁女性的横断面研究中，我们测量了Hb和铁状态生物标志物。利用受试者工作特征曲线，我们确定了检测ID的具有最大Youden指数的Hb阈值。
In South Africa, haemoglobin (Hb) is measured to screen for iron deficiency (ID). However, low levels of Hb are only a late stage indicator of ID. Furthermore, Hb values are generally not adjusted for altitude even though recommended by WHO. We determined the Hb threshold with the highest combined sensitivity and specificity for detecting ID among South African women living at 1700 m above sea level. In a cross-sectional study of 492 18-25-year-old women, we measured Hb and iron status biomarkers. Using receiver operating characteristic curves, we determined the Hb threshold with maximum Youden Index for detecting ID. This threshold of