Clocking skin sodium.
Clocking skin sodium.
复制标题
记录皮肤钠。
DOI：
10.1152/ajpregu.00453.2017
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Gumz,MichelleL
中科院分区：
文献类型：
--
作者：
Gumz,MichelleL
高血压仍然是一个重大的全球健康负担，并被广泛认为是18个单一的最大风险因素过早死亡和疾病（审查（7，8）。几个主要临床学会最近发布的新的19指南将高血压重新定义为130/80 20 mm Hg，这意味着近一半的美国人现在被认为是高血压。需要采取新的21种方法来应对这一公共卫生流行病。22来自多种动物模型的数十年证据增加了我们对23有助于整体血压24调节的分子途径的数量和复杂性的理解。尽管有大量的新发现，高血压仍然是全球疾病负担和死亡的主要危险因素。这可能反映了我们对血压调节的26种机制缺乏了解。啮齿动物模型研究的大部分注意力集中在单个器官系统、肾脏、大脑和血管系统。更少的注意力已经给予其他器官系统，如皮肤，这也可能有助于29调节。动物研究中另一个经常被忽视的参数是时间的作用。啮齿类动物模型是研究心血管功能和疾病的有力工具，但它们的夜间活动特性常常被忽视。在本期《美国生理学-调节杂志》中，32综合和比较生理学，Speed等人通过探索盐敏感性高血压大鼠模型中皮肤Na储存在昼夜节律周期过程中的作用，解决了时间和经常被低估的器官系统的作用（新参考文献）。35
Hypertension remains a significant global health burden and is widely considered the 18 single greatest risk factor for premature death and disease (reviewed in (7, 8). The new 19 guidelines recently issued by several major clinical societies redefined hypertension as 130/80 20 mm Hg, meaning that nearly half of all Americans are now considered hypertensive (7). New 21 approaches are needed to address this public health epidemic. 22Decades of evidence from multiple animal models has increased our understanding of 23 the number and complexity of the molecular pathways that contribute to overall blood pressure 24 regulation. Despite a plethora of new findings, hypertension continues to persist as a global 25 disease burden and major risk factor for death. This may reflect our lack of understanding of the 26 mechanisms underlying blood pressure regulation. Much attention from research in rodent 27 models has focused on single organ systems, the kidney, brain, and vasculature. Much less 28 attention has been given to other organ systems, such as the skin, that also likely contribute to 29 regulation. Another often neglected parameter in animal studies is the role of time. Rodent 30 models are powerful tools for studying cardiovascular function and disease yet their nocturnal 31 nature is often overlooked. In this issue of the American Journal of Physiology-Regulatory, 32 Integrative and Comparative Physiology, Speed et al. address both the role of time and an often 33 underappreciated organ system by exploring the role of skin Na storage over the course of the 34 circadian cycle in a rat model of salt-sensitive hypertension (new ref). 35