CALCITONIN GENE-RELATED PEPTIDE, A PEPTIDE PRESENT IN SPINAL-CORD MOTONEURONS, INCREASES THE NUMBER OF ACETYLCHOLINE-RECEPTORS IN PRIMARY CULTURES OF CHICK-EMBRYO MYOTUBES
CALCITONIN GENE-RELATED PEPTIDE, A PEPTIDE PRESENT IN SPINAL-CORD MOTONEURONS, INCREASES THE NUMBER OF ACETYLCHOLINE-RECEPTORS IN PRIMARY CULTURES OF CHICK-EMBRYO MYOTUBES
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DOI：
10.1016/0304-3940(86)90257-0
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发表时间：
1986-10-30
影响因子：
2.5
通讯作者：
CHANGEUX, JP
中科院分区：
文献类型：
--
作者：
FONTAINE, B;KLARSFELD, A;CHANGEUX, JP
用免疫组织化学方法，我们表明，降钙素基因相关肽（CGRP，由降钙素基因编码的肽）存在于鸡脊髓运动神经元。当添加到培养的鸡肌管中时，CGRP导致表面乙酰胆碱受体水平平均增加1.5倍。此外，CGRP的效果是独立的河豚毒素，膜电活动的阻滞剂，但不是由霍乱毒素，腺苷酸环化酶的激活剂所造成的。
Using immunohistochemical methods we show that calcitonin gene-related peptide (CGRP, a peptide encoded by the calcitonin gene) is present in chick spinal cord motoneurons. When added to cultured chicken myotubes, CGRP caused an average 1,5-fold increase in levels of surface acetylcholine receptors. Moreover, the effect of CGRP was independent of the one produced by tetrodotoxin, a blocker of membrane electrical activity but not of that caused by cholera toxin, an activator of adenylate cyclase.