PATTERNS OF METABOLIC ADAPTATION FOR PRETERM AND TERM INFANTS IN THE 1ST NEONATAL WEEK
PATTERNS OF METABOLIC ADAPTATION FOR PRETERM AND TERM INFANTS IN THE 1ST NEONATAL WEEK
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DOI：
10.1136/adc.67.4_spec_no.357
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发表时间：
1992-04-01
影响因子：
4.4
通讯作者：
AYNSLEYGREEN, A
中科院分区：
文献类型：
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作者：
HAWDON, JM;PLATT, MPW;AYNSLEYGREEN, A
对156名足月儿和62名早产儿进行了一项横断面研究，以确定出生后第一周血糖和中间代谢物的正常范围和相互关系，并与52名年龄较大的儿童进行比较。早产儿的血糖浓度变化大于足月儿（1.5-12.2 mmol/l-nu-1.5-6.2 mmol/l），早产儿的酮体浓度较低，即使在低血糖浓度下也是如此。足月儿的母乳喂养和早产儿的肠内喂养似乎可以增强生酮能力。足月儿的餐前血糖浓度低于儿童，但像儿童一样，似乎能够产生ketone bodies.This study demonstrates，新生儿血糖浓度应考虑在其他代谢燃料的可用性的背景下，早产儿动员替代燃料的能力有限。
There have been few comprehensive accounts of the relationships between glucose and other metabolic fuels during the first postnatal week, especially in the context of modern feeding practises.A cross sectional study was performed of 156 term infants and 62 preterm infants to establish the normal ranges and interrelationships of blood glucose and intermediary metabolites in the first postnatal week, and to compare these with those of 52 older children. Blood glucose concentrations varied more for preterm than for term infants (1.5-12.2 mmol/l-nu-1.5-6.2 mmol/l), and preterm infants had low ketone body concentrations, even at low blood glucose concentrations. Breast feeding of term infants and enteral feeding of preterm infants appeared to enhance ketogenic ability. Term infants had lower prefeed blood glucose concentrations than children but, like children, appeared to be capable of producing ketone bodies.This study demonstrates that neonatal blood glucose concentrations should be considered in the context of availability of other metabolic fuels, and that the preterm infant has a limited ability to mobilise alternative fuels.