NetworkBLAST: comparative analysis of protein networks
NetworkBLAST: comparative analysis of protein networks
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DOI：
10.1093/bioinformatics/btm630
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发表时间：
2008-02-15
期刊：
影响因子：
5.8
通讯作者：
Sharan, Roded
中科院分区：
文献类型：
--
作者：
Kalaev, Maxim;Smoot, Mike;Sharan, Roded
蛋白质复合物的识别是解释蛋白质相互作用数据的一个基本挑战。跨物种分析可以应对这些数据中典型的高噪声水平。NetworkBLAST网络服务器提供了一个平台，用于识别蛋白质相互作用网络中的蛋白质复合物。它可以分析单个网络或来自不同物种的两个网络。在后一种情况下，NetworkBLAST输出一组在两个网络中进化保守的推定复合物。
The identification of protein complexes is a fundamental challenge in interpreting proteinprotein interaction data. Cross-species analysis allows coping with the high levels of noise that are typical to these data. The NetworkBLAST web-server provides a platform for identifying protein complexes in protein-protein interaction networks. It can analyze a single network or two networks from different species. In the latter case, NetworkBLAST outputs a set of putative complexes that are evolutionarily conserved across the two networks.