Cold agglutinin disease revisited: a multinational, observational study of 232 patients
Cold agglutinin disease revisited: a multinational, observational study of 232 patients
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DOI：
10.1182/blood.2020005674
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发表时间：
2020-07-23
期刊：
影响因子：
20.3
通讯作者：
Tjonnfjord, Geir E.
中科院分区：
文献类型：
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作者：
Berentsen, Sigbjorn;Barcellini, Wilma;Tjonnfjord, Geir E.
我们回顾性研究了5个国家24个中心的232例冷凝集素病（CAD）患者。在挪威和意大利的北方地区，这项研究接近于以人口为基础。我们第一次证明了寒冷和温暖气候之间在患病率（20 vs 5例/百万）和发病率（每年1.9 vs 0.48例/百万）方面的四倍差异。平均基线血红蛋白水平为9.3 g/dL，但27%的患者血红蛋白水平
We retrospectively studied 232 patients with cold agglutinin disease (CAD) at 24 centers in 5 countries. In Norway and a northern region of Italy, the study was close to being population-based. For the first time, we demonstrate fourfold differences between cold and warmer climates regarding prevalence (20 vs 5 cases/million) and incidence (1.9 vs 0.48 cases/million per year). Mean baseline hemoglobin level was 9.3 g/dL, but 27% had hemoglobin