ONTOGENY OF THE SEROTONERGIC SYSTEM IN THE RAT - SEROTONIN AS A DEVELOPMENTAL SIGNAL
ONTOGENY OF THE SEROTONERGIC SYSTEM IN THE RAT - SEROTONIN AS A DEVELOPMENTAL SIGNAL
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DOI：
10.1111/j.1749-6632.1990.tb16891.x
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发表时间：
1990-10-15
影响因子：
5.2
通讯作者：
LAUDER, JM
中科院分区：
文献类型：
--
作者：
LAUDER, JM
5-羟色胺能系统是中枢神经系统回路的早期形成成分，在大鼠妊娠11-12天开始发育。由于早期存在于胚胎神经系统，5-羟色胺被认为是感受性细胞的发育信号。体内和体外证据表明，5-羟色胺可以影响中缝神经元和感受性靶细胞的生化和形态分化，提示这种神经递质可能在发育中的神经系统中具有组织功能，包括影响神经突起的生长和神经元分化的其他方面，包括突触形成。这些功能可能是由神经细胞和非神经细胞上的各种5-羟色胺受体介导的。5-羟色胺在发育中的神经系统中作为分化信号的明显作用引发了孕妇使用精神活性5-羟色胺能药物的重要问题，因为这些药物可能会在未出生的婴儿中起到神经畸形物的作用。
The serotonergic system is an early forming component of the CNS circuitry, beginning its development on gestational days 11-12 in the rat. Owing to its early presence in the embryonic nervous system, 5-HT has been proposed to act as a developmental signal for receptive cells. In vivo and in vitro evidence that 5-HT can influence both biochemical and morphological differentiation of raphe neurons and receptive target cells suggests that this neurotransmitter may have an organizing function in the developing nervous system which involves effects on neurite outgrowth and other aspects of neuronal differentiation, including synaptogenesis. Such functions may be mediated by a variety of 5-HT receptors located on both neuronal and non-neuronal cells. The apparent function of 5-HT as a differentiation signal in the developing nervous system raises important issues regarding the use of psychoactive serotonergic drugs by pregnant women, since these drugs may act as neural teratogens in the unborn child.