Eco-friendly synthesis of regenerable antimicrobial polymeric resin with N-halamine and quaternary ammonium salt groups
Eco-friendly synthesis of regenerable antimicrobial polymeric resin with N-halamine and quaternary ammonium salt groups
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DOI：
10.1039/c3ra47147k
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发表时间：
2014-01-01
期刊：
影响因子：
3.9
通讯作者：
Liang, Jie
中科院分区：
文献类型：
--
作者：
Jie, Zhiqiang;Yan, Xiufang;Liang, Jie
采用环保经济的方法合成了一种含n -卤胺和季铵盐的高效大孔交联抗菌高分子树脂。市售的大孔交联氯甲基化聚苯乙烯（CMPS）树脂与5,5-二甲基苯乙烯（DMH）盐和三甲胺（TMA）在水中反应，制得含有苯乙烯基和季铵盐基团的聚合树脂聚（对甲基苯乙烯）-3-（5,5-二甲基苯乙烯）-co-三甲基氯化铵（PSHTMA）。在稀NaOCl溶液中，通过易氯化反应将PSHTMA中的羟基转化为具有抗菌作用的n -卤胺结构。用FT-IR、x射线光电子能谱和ζ电位对合成的抗菌高分子树脂（Cl-PSHTMA）进行了表征。抗菌实验表明，合成的抗菌高分子树脂在1分钟接触时间内对金黄色葡萄球菌和大肠杆菌的灭活能力分别为7对数和8对数。此外，Cl-PSHTMA中的N-halamine基团表现出优异的可再生性。
An effective macroporous cross-linked antimicrobial polymeric resin containing N-halamine and quaternary ammonium salt moieties was synthesized in an eco-friendly and economical way. Commercially available macroporous crosslinked chloromethylated polystyrene (CMPS) resin reacted with the salt of 5,5-dimethylhydantoin (DMH) and trimethylamine (TMA) in water to produce a polymeric resin containing hydantoinyl and quaternary ammonium salt moieties, poly(p-methylstyrene)-3-(5,5-dimethylhydantoin)-co- trimethyl ammonium chloride (PSHTMA). The hydantoinyl groups in PSHTMA were converted to an antimicrobial N-halamine structure by a facile chlorination reaction in dilute NaOCl solution. The as-synthesized antimicrobial polymeric resin (Cl-PSHTMA) was characterized by FT-IR, X-ray photoelectron spectroscopy, and zeta-potential measurement. The antimicrobial tests showed that the as-synthesized antimicrobial polymeric resin was capable of 7-log inactivation of S. aureus and 8-log inactivation of E. coli within 1 minute contact time. Moreover, the N-halamine moieties in Cl-PSHTMA exhibited excellent regenerability.