Transcranial direct current stimulation of the motor cortex induces distinct changes in thermal and mechanical sensory percepts
Transcranial direct current stimulation of the motor cortex induces distinct changes in thermal and mechanical sensory percepts
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DOI：
10.1016/j.clinph.2010.05.005
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发表时间：
2010-12-01
影响因子：
4.7
通讯作者：
Happe, Svenja
中科院分区：
文献类型：
--
作者：
Bachmann, Cornelius G.;Muschinsky, Sebastian;Happe, Svenja
目的：这项单盲、完全交叉研究的目的是通过定量感觉测试 (QST) 评估 tDCS 对热感知和机械感知的影响。方法：对 8 名健康受试者（3 名女性，5 名男性，25-41 岁）的双手桡侧部分进行 QST。这些受试者在以随机顺序应用阴极、阳极或假 tDCS 之前和之后接受检查。 TDCS 以 1 mA 电流强度进行 15 分钟，活性电极放置在左侧初级运动皮层上方，参考电极放置在右眼眶上方。结果：与基线条件相比，阴极 tDCS 后，对侧手的冷检测阈值 (CDT)、机械检测阈值 (MDT) 和机械疼痛阈值 (MPT) 显着增加。结论：阴极 tDCS 暂时降低了对 A 纤维介导的敏感性意义：这些体感感知的损害表明在阴极 tDCS 刺激运动皮层后，丘系或丘脑上的感觉通路会受到短期抑制。 (C) 2010 年国际临床神经生理学联合会。由爱思唯尔爱尔兰有限公司出版。保留所有权利。
Objective: The aim of this single-blinded, complete crossover study was to evaluate the effects of tDCS on thermal and mechanical perception, as assessed by quantitative sensory testing (QST).Methods: QST was performed upon the radial part of both hands of eight healthy subjects (3 female, 5 male, 25-41 years of age). These subjects were examined before and after cathodal, anodal or sham tDCS, applied in a random order. TDCS was administered for 15 min at a 1 mA current intensity, with the active electrode placed over the left primary motor cortex and the reference electrode above the right orbit.Results: After cathodal tDCS, cold detection thresholds (CDT), mechanical detection thresholds (MDT), and mechanical pain thresholds (MPT) significantly increased in the contralateral hand, when compared to the baseline condition.Conclusions: Cathodal tDCS temporarily reduced the sensitivity to A-fiber mediated somatosensory inputs.Significance: Impairment of these somatosensory percepts suggests a short-term suppression of lemniscal or suprathalamic sensory pathways following motor cortex stimulation by cathodal tDCS. (C) 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.