ANTIOXIDANT ACTIVITY OF DIBENZOCYCLOOCTENE LIGNANS ISOLATED FROM SCHISANDRACEAE
ANTIOXIDANT ACTIVITY OF DIBENZOCYCLOOCTENE LIGNANS ISOLATED FROM SCHISANDRACEAE
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DOI：
10.1055/s-2006-961473
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发表时间：
1992-08-01
期刊：
影响因子：
2.7
通讯作者：
LIU, GT
中科院分区：
文献类型：
--
作者：
LU, H;LIU, GT
从北五味子、rubriflora和长梗水葫芦Kadelongipedunculata。7的9木脂素（1毫米）抑制铁/半胱氨酸诱导的脂质过氧化（丙二醛，MDA，形成）的大鼠肝微粒体，以及超氧阴离子的生产中的黄嘌呤/黄嘌呤氧化酶系统。7种木脂素的抗氧化作用均强于维生素E，其中以五味子酚的抗氧化作用最强。该化合物还防止铁/半胱氨酸诱导的肝微粒体膜流动性降低。结果表明，五味子酚等7种木脂素具有抗氧化活性。
The anti-oxidant activity of nine dibenzocyclooctene lignans isolated from Schisandra chinensis, S. rubriflora, and Kadsura longipedunculata, respectively, was studied. Seven of the 9 lignans (1 mM) inhibited iron/cysteine-induced lipid peroxidation (malondialdehyde, MDA, formation) of rat liver microsomes as well as superoxide anion production in the xanthine/xanthine oxidase system. The actions of the 7 lignans were much more potent than vitamin E at the same concentration of 1 mM. Among the lignans, schisanhenol was the most active one. This compound also prevented the decrease of membrane fluidity of liver microsomes induced by iron/cysteine. The results indicated that seven of the lignans such as schisanhenol have anti-oxidant activities.