Effects of a single pre-operative dexmedetomidine dose on isoflurane requirements and peri-operative haemodynamic stability
Effects of a single pre-operative dexmedetomidine dose on isoflurane requirements and peri-operative haemodynamic stability
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DOI：
10.1111/j.1365-2044.1997.169-az0303.x
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发表时间：
1997-08-01
期刊：
影响因子：
10.7
通讯作者：
DeLange, S
中科院分区：
文献类型：
--
作者：
Lawrence, CJ;DeLange, S
在一项双盲、安慰剂对照研究中，我们研究了50例接受骨科和普外科小手术的患者诱导前单次静脉注射2 mu右美托咪定（g.kg（-1））对麻醉要求和围手术期血流动力学稳定性的影响。患者用一氧化二氮/氧气/芬太尼麻醉，必要时补充异氟烷。右美托咪定治疗患者的平均（SD）术中异氟烷浓度低于对照组（0.01（0.03）%与0.1（0.1）%; p = 0.001），尽管25例治疗患者中有6例在某个阶段需要异氟烷。右美托咪定组对气管插管和拔管的血流动力学反应降低，如术中心率变异性;右美托咪定组的术后镇痛和止吐需求以及围手术期血清儿茶酚胺浓度较低。右美托咪定给药后，低血压和心动过缓的发生率更高。
In a double-blind, placebo-controlled study we investigated the effect of a single pre-induction intravenous dose of dexmedetomidine 2 mu g.kg(-1) on anaesthetic requirements and peri-operative haemodynamic stability in 50 patients undergoing minor orthopaedic and general surgery. Patients were anaesthetised with nitrous oxide/oxygen/fentanyl, supplemented if necessary with isoflurane. The mean (SD) intra-operative isoflurane concentration was lower in the dexmedetomidine-treated patients than controls (0.01 (0.03)% compared to 0.1 (0.1)%; p = 0.001) although six of the 25 treated patients required isoflurane at some stage. The haemodynamic response to tracheal intubation and extubation was reduced in the dexmedetomidine group as uas intra-operative heart rate variability; postoperative analgesic and anti-emetic requirements and peri-operative serum catecholamine concentrations were lower in the dexmedetomidine group. Hypotension and bradycardia occurred more frequently after dexmedetomidine.