Effects of PQQ on cognitive function induced by MK801 and its molecular imaging evaluation
Effects of PQQ on cognitive function induced by MK801 and its molecular imaging evaluation
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PQQ对MK801诱导认知功能的影响及其分子影像评价
DOI：
10.1016/j.ijdevneu.2015.04.078
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发表时间：
2015-12
影响因子：
1.8
通讯作者：
X.J.Xu
中科院分区：
文献类型：
--
作者：
X.Q. Zhou;Q.C. Chen;S.S. Mao;X.F. Qin;X.J.Xu
讨论：PET成像显示MK-801诱导小鼠的皮质/小脑放射性摄取比正常小鼠降低。利培酮干预后，皮质/小脑放射性摄取增加。随着PQQ剂量的增加，该值也增加。结果表明，如果以适当的剂量使用，PQQ可以防止MK-801诱导的认知缺陷的发展，这表明了人类精神分裂症的新治疗方法。http：//dx. doi。org/10.1016/j. ijdevneu。2015.04. 078
Discussion: PET imaging showed that the radioactivity uptake of the cortex/cerebellar decreased in the MK-801-induced mice than in normal. After intervention by risperidone, the cortex/cerebellar radioactivity uptake was increased. The value was also increased with increase of PQQ dose. The results indicate that PQQ may prevent the development of MK-801-induced cognitive deficits if used in appropriate doses, which suggests new treatment approaches for schizophrenia in humans. http://dx. doi. org/10.1016/j. ijdevneu. 2015.04. 078