Endometrial receptivity: Changes in cell-surface morphology
Endometrial receptivity: Changes in cell-surface morphology
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DOI：
10.1055/s-2000-12561
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发表时间：
2000-01-01
影响因子：
2.7
通讯作者：
Nikas, G
中科院分区：
文献类型：
--
作者：
Nikas, G
排卵和受精通过黄体孕酮的产生启动胚胎发育和子宫内膜分化。这两个同步的过程在大约一周后结合在一起，当胚泡开始植入MoW接受性子宫内膜(着床窗口)。容受性是子宫内膜分化的一种状态，以上皮形态的变化为标志：毛状细胞微绒毛融合成单一的花状膜突起，称为“管脚”。连续子宫内膜活检的扫描电子显微镜显示，针脚形成的时间很短(1-2天)，其数量与着床有关。平均而言，与自然周期(20-21天)相比，刺激(19-20天)和人工(21-22天)更早形成针脚。然而，在形成松足的周期中，女性之间有很大的差异(长达5天)。这些结果表明，在人类体内存在一个狭窄而离散的植入窗口。针脚的检测是评估子宫内膜容受性的一个潜在的临床标志物。
Ovulation and fertilization trigger embryonic development and endometrial differentiation by corpus luteum progesterone production. These two synchronous processes couple about I week later, when the blastocyst begins to implant in the Mow receptive endometrium (implantation window). Receptivity is a state of endometrial differentiation marked by a change in epithelial morphology: the hairy-like cell microvilli fuse to a single flower-like membrane projection called the "pinopode." Scanning electron microscopy of sequential endometrial biopsies shows that pinopodes form briefly (1-2 days), and their numbers correlate with implantation. On average, the formation of pinopodes is earlier in stimulated (days 19-20) and later in artificial (days 21-22) compared with natural cycles (days 20-21). There is, however, a wide (up to 5 days) variation between women in the cycle days on which pinopodes form. These results suggest the existence of a narrow and discrete implantation window in humans. Detection of pinopodes is a potential clinical marker to assess endometrial receptivity.