Predictors of motor development in children prenatally exposed to cocaine
Predictors of motor development in children prenatally exposed to cocaine
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DOI：
10.1016/j.ntt.2004.10.007
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发表时间：
2005-03-01
影响因子：
2.9
通讯作者：
Liu, J
中科院分区：
文献类型：
--
作者：
Miller-Loncar, C;Lester, BM;Liu, J
目前的研究检查了子宫内接触可卡因的婴儿出生后18个月的运动发育模式，以确定产前药物效应和暴露水平与运动发育的关系。在1、4、12和18个月大时检查运动发育（校正早产）。将婴儿分为可卡因暴露组（n=392）和对照组（n=776）。两组均存在酒精、大麻、烟草和阿片类药物，通过胎便测定和产妇自我报告确定暴露状态。运动技能在1个月时使用NICU网络神经行为量表（NNNS）， 4个月时使用婴儿姿势和精细运动评估量表（PFMAI）， 12个月时使用Bayley婴儿发育量表-第二版（bsidi - ii）， 18个月时使用Peabody发育运动量表（PDMS）。掩盖暴露状态的检查人员进行了所有评估。将运动得分转换为标准(z)得分，并使用层次线性模型（HLM）来检查1至18个月大运动技能的变化。接触可卡因的婴儿在1个月大时表现出较低的运动技能，但随着时间的推移表现出显著的提高。平均而言，较高和较低水平的烟草使用都与较差的运动表现有关。与不使用相比，大量使用可卡因与较差的运动表现有关，但可卡因使用水平对运动技能的改变没有影响。(c) 2004 Elsevier Inc.版权所有。
The current study examined the pattern of motor development across the first 18 months of life in infants with in utero exposure to cocaine to determine how prenatal drug effects and level of exposure relates to motor development. Motor development was examined at 1, 4, 12, and 18 months of age (corrected for prematurity). Infants were divided into cocaine exposed (n=392) and comparison (n=776) groups. Exposure status was determined by meconium assay and maternal self-report with alcohol, marijuana, tobacco, and opiates present in both groups. Motor skills were assessed at 1 month using the NICU Network Neurobehavioral Scale (NNNS), at 4 months using the posture and fine motor assessment of infants (PFMAI), at 12 months using the Bayley Scales of Infant Development-Second Edition (BSID-II), and at 18 months using the Peabody Developmental Motor Scales (PDMS). Examiners masked to exposure status performed all assessments. Motor scores were converted to standard (z) scores, and hierarchical linear modeling (HLM) was used to examine the change in motor skills from 1 to 18 months of age. Infants with exposure to cocaine showed low motor skills at their initial status of 1 month but displayed significant increases over time. Both higher and lower levels of tobacco use related to poorer motor performance on average. Heavy cocaine use related to poorer motor performance as compared to no use, but there were no effects of level of cocaine use on change in motor skills. (c) 2004 Elsevier Inc. All rights reserved.