Left atrial volume, geometry, and function in systolic and diastolic heart failure of persons ≥65 years of age (The Cardiovascular Health Study)
Left atrial volume, geometry, and function in systolic and diastolic heart failure of persons ≥65 years of age (The Cardiovascular Health Study)
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DOI：
10.1016/j.amjcard.2005.07.126
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发表时间：
2006-01-01
影响因子：
2.8
通讯作者：
Manolio, TA
中科院分区：
文献类型：
--
作者：
Gottdiener, JS;Kitzman, DW;Manolio, TA
左心房增大与许多因素有关，包括衰老、心房颤动、高血压、舒张功能障碍和低射血分数心力衰竭。然而，在舒张期和收缩期HF之间，左房（LA）容积、几何形状和排空尚未比较，在许多射血分数正常的老年受试者中，也没有确定左房容积与新发HF的关系。我们使用超声心动图测量了851名65岁社区居民的LA容积、几何形状和排空，其中包括180名基线时患有HF的参与者和255名随后发展为HF的参与者。与合并症和多普勒舒张功能测量结果无关，流行和突发HF组的左心室容积、面积和线性尺寸均高于对照组，收缩期和舒张期HF组之间无差异。部分面积变化与普遍的HF有关，但与偶发的HF无关。总之，在以人群为基础的老年受试者中，收缩期或舒张期HF患者的LA大小增加，LA排空减少。LA大小与HF的新发展有关。这些发现强调了左心房在HF中的重要作用，无论是否有射血分数降低。(c) 2006爱思唯尔公司版权所有。
The left atrium enlarges in association with many factors, including aging, atrial fibrillation, hypertension, diastolic dysfunction, and heart failure (HF) with low ejection fraction. However, left atrial (LA) volume, geometry, and emptying have not been compared between diastolic and systolic HF, nor has the association of LA volume for new HF been determined in older subjects, many of whom have normal ejection fraction. We used echocardiography to measure the LA volume, geometry, and emptying in 851 community-dwelling subjects >= 65 years of age, including 180 with HF at baseline and 255 participants who subsequently developed HF. The LA volume, area, and linear dimensions were higher in the prevalent and incident HF groups than in controls and did not differ between those with systolic versus diastolic HF, independent of co-morbidities and Doppler measures of diastolic function. The fractional area change was associated with prevalent, but not incident, HF. In conclusion, in population-based older subjects, the LA size is increased and LA emptying decreased in patients with either systolic or diastolic HF. LA size is associated with the new development of HF. These findings highlight the important role of the left atrium in HF, with or without a decreased ejection fraction. (c) 2006 Elsevier Inc. All rights reserved.