A 3D map of the islet routes throughout the healthy human pancreas.
A 3D map of the islet routes throughout the healthy human pancreas.
复制标题
DOI：
10.1038/srep14634
复制
发表时间：
2015-09-29
影响因子：
4.6
通讯作者：
Militaru M
中科院分区：
文献类型：
--
作者：
Ionescu-Tirgoviste C;Gagniuc PA;Gubceac E;Mardare L;Popescu I;Dima S;Militaru M
胰岛是了解糖尿病的基础。来自供体的健康人胰腺已被用于评估各种胰岛参数及其三维分布。在这里，我们表明，胰岛是逐渐蔓延，从头部到尾部部分的胰腺的形式收缩或扩张的胰岛路线。我们还报告了一种特殊的解剖结构，即胰岛簇。我们的观察结果显示，总共有11个胰岛簇，由围绕大血管的小胰岛组成。在胰腺周围脂肪组织中的额外观察显示了在局部炎症过程中捕获的淋巴样结节和血管。我们的观察是基于胰腺的区域切片图，包括5，423个胰岛。我们还设计了一个球形指数，它简要地表明了在整个胰腺中占主导地位的各种胰岛形状。
Islets of Langerhans are fundamental in understanding diabetes. A healthy human pancreas from a donor has been used to asses various islet parameters and their three-dimensional distribution. Here we show that islets are spread gradually from the head up to the tail section of the pancreas in the form of contracted or dilated islet routes. We also report a particular anatomical structure, namely the cluster of islets. Our observations revealed a total of 11 islet clusters which comprise of small islets that surround large blood vessels. Additional observations in the peripancreatic adipose tissue have shown lymphoid-like nodes and blood vessels captured in a local inflammatory process. Our observations are based on regional slice maps of the pancreas, comprising of 5,423 islets. We also devised an index of sphericity which briefly indicates various islet shapes that are dominant throughout the pancreas.