Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder
Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder
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DOI：
10.1002/da.20064
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发表时间：
2005-01-01
影响因子：
7.4
通讯作者：
Paik, IH
中科院分区：
文献类型：
--
作者：
Lee, HJ;Lee, MS;Paik, IH
创伤后应激障碍（PTSD）是一种以行为、生理和激素改变为特征的普遍存在的焦虑症。PTSD的病因尚不清楚，尽管暴露于创伤性事件是一个必要的，但不是充分的因素。5-羟色胺能功能障碍与创伤后应激障碍有关。本研究探讨了可能的联系之间的阿托宁转运蛋白连锁多态性区域（SERTPR）和创伤后应激障碍。采用病例对照设计，分析了100例PTSD患者和197例无关健康对照的SERTPR基因型和等位基因频率。PTSD患者s/s基因型频率显著高于正常对照组。提示SERTPR s/s基因型是PTSD易感性的遗传因素之一。需要进一步研究基因多态性对PTSD的生物学机制、临床表现和治疗反应的影响。抑郁和焦虑21：135-139，2005. (c)2005 Wiley-Liss，Inc.
Posttraumatic stress disorder (PTSD) is a prevalent anxiety disorder marked by behavioral, physiologic, and hormonal alterations. The etioloxy of PTSD is unknown, although exposure to a traumatic event constitutes a necessary, but not Sufficient, factor. Serotonergic dysfunction has been implicated in PTSD. The present study examined the possible association between the serotonin-transporter-linked polymorphic region (SERTPR) and PTSD. The genotype and allele frequencies of the SERTPR were analyzed in 100 PTSD patients and 197 unrelated healthy controls using a case-control design. The frequency of the s/s genotype was significantly higher in PTSD patients than in normal controls. These findings suggest that the SERTPR s/s genotype is one of the genetic factors for the susceptibility to PTSD. Further investigations are required into the influence of gene polymorphisms on the biological mechanisms of PTSD, its clinical expression, and its response to treatment. Depression and Anxiety 21:135-139, 2005. (c) 2005 Wiley-Liss, Inc.