Positive Association Between Serum Levels of High-Sensitivity C-Reactive Protein and Depression/Anxiety in Female, but Not Male, Patients With Type 2 Diabetes Mellitus
Positive Association Between Serum Levels of High-Sensitivity C-Reactive Protein and Depression/Anxiety in Female, but Not Male, Patients With Type 2 Diabetes Mellitus
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DOI：
10.1177/1099800419894641
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发表时间：
2019-12
影响因子：
2.5
通讯作者：
Qian-Qian Yang-Qian;Di Shao;Jie Li;Chunlian Yang;Min-Hua Fan;F. Cao
中科院分区：
文献类型：
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作者：
Qian-Qian Yang-Qian;Di Shao;Jie Li;Chunlian Yang;Min-Hua Fan;F. Cao
目的：2型糖尿病（T2D）患者抑郁和焦虑的风险增加。有证据表明，炎症状态的加剧可能促成了这种关联。女性比男性更容易抑郁，炎症水平也更高。本研究比较了2型糖尿病（T2DM）男女患者血清高敏c反应蛋白（hs-CRP）水平与抑郁和焦虑症状的关系。方法：收集来自山东省某综合医院的392例T2DM患者的横断面资料，包括人口统计学和疾病特征、抑郁和焦虑症状、临床资料和实验室值。我们分别使用多元线性回归和χ2趋势检验评估了男性和女性血清hs-CRP水平与抑郁和焦虑症状之间的关系。结果：性别调节血清hs-CRP水平与抑郁症状（B = 0.112 [SE = 0.049]; p = 0.022）和焦虑症状（B = 0.137 [SE = 0.053]; p = 0.011）的相关性。在女性中，hs-CRP水平与抑郁症呈正相关(B = 0.034, 95%可信区间[CI] =[。006年,.061];p = 0.016，假发现率[FDR]调整后p = 0.020)和焦虑(B = 0.041, 95% CI[。011年,。[71], p = .007，经罗斯福调整的p = .007)。阳性趋势表明，在血清hs-CRP类别较高的女性中，有临床意义的抑郁和焦虑症状的患病率较高。在男性中没有发现关联。结论：研究结果表明，血清hs-CRP水平与T2D患者抑郁和焦虑症状之间存在性别特异性，只有女性表现出显著的正相关。
Purpose: Patients with Type 2 diabetes (T2D) have increased risk of depression and anxiety. Evidence suggests that a heightened inflammatory state may contribute to this association. Females experience more depression and higher inflammation levels than males. This study compared associations of serum high-sensitivity C-reactive protein (hs-CRP) levels with symptoms of depression and anxiety between men and women with Type 2 diabetes mellitus (T2DM). Method: Cross-sectional data including demographic and disease characteristics, symptoms of depression and anxiety, clinical data, and laboratory values were collected from 392 patients with T2DM recruited from a general hospital in Shandong Province, China. We evaluated associations between serum hs-CRP level and symptoms of depression and anxiety in males and females separately using multiple linear regressions and χ2 tests for trend. Results: Sex moderated the association between serum hs-CRP level and symptoms of depression (B = .112 [SE = 0.049]; p = .022) and anxiety (B = .137 [SE = 0.053]; p = .011). Among females, hs-CRP level was positively associated with depression (B = .034, 95% confidence interval [CI] = [.006, .061]; p = .016, false discovery rate [FDR]-adjusted p = .020) and anxiety (B = .041, 95% CI [.011, .071], p = .007, FDR-adjusted p = .007). Positive trends indicated a higher prevalence of clinically significant symptoms of depression and anxiety in higher serum hs-CRP categories in females. No associations were found in males. Conclusion: Findings demonstrate that associations between serum hs-CRP level and symptoms of depression and anxiety in patients with T2D are sex-specific, with only females demonstrating a significant positive association.