A SYSTEM OF RAT SPINAL-CORD LAMINA-1 CELLS PROJECTING THROUGH THE CONTRALATERAL DORSOLATERAL FUNICULUS
A SYSTEM OF RAT SPINAL-CORD LAMINA-1 CELLS PROJECTING THROUGH THE CONTRALATERAL DORSOLATERAL FUNICULUS
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DOI：
10.1002/cne.902140209
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发表时间：
1983-01-01
影响因子：
2.5
通讯作者：
WALL, PD
中科院分区：
文献类型：
--
作者：
MCMAHON, SB;WALL, PD
对具有长上升突起的I层神经元的性质进行了采样。在L[腰椎]4/5水平记录136个单位，上行轴突到达C[颈椎]2。超过80%的单位通过对侧背外侧白质投射，只有10%通过对侧腹象限投射。没有通过背柱投射。接受野通常为1-2平方厘米，尽管大量的单位对有限范围的强烈刺激作出反应，但更多的单位被低阈值和高阈值刺激激发。与深层层状细胞相比，大多数单位在背外侧索下降通路激活后兴奋。这些单元的功能作用并不明显，但上升投射的位置和下降通路的影响并不支持第1层输出构成简单疼痛通路的观点。
The properties of lamina I neurons with long ascending projections were sampled. Recordings were made from 136 units at the L[lumbar]4/5 level, with ascending axons reaching C[cervical]2. More than 80% of the units projected via the contralateral dorsolateral white matter and only 10% via the contralateral ventral quadrant. None projected via the dorsal columns. Receptive fields were typically 1-2 cm2 and although a substantial number of units responded to a limited range of intense stimuli, a greater number of units were fired by both low- and high-threshold stimulation. In contrast to cells of deeper laminae, the majority of units were excited following activation of descending pathways in the dorsolateral funiculus. The functional role of these units is not obvious, but the location of the ascending projection and the influence of descending pathways does not support the notion that the output of lamina 1 constitutes a simple pain pathway.