[Spontaneous neonatal aortic thrombosis revealing protein S deficiency].
[Spontaneous neonatal aortic thrombosis revealing protein S deficiency].
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DOI：
10.1016/j.jdmv.2017.11.007
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发表时间：
2018-02-01
期刊：
影响因子：
--
通讯作者：
Barkat, A
中科院分区：
文献类型：
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作者：
Ayad, A;Lemouakni, S;Barkat, A
新生儿动脉血栓形成是罕见的，并与预后不良，往往归因于脐动脉插管。主动脉型和自发型是例外。其严重性需要快速有效的治疗。虽然治疗手段很多，但迄今为止尚未达成共识，尽管溶栓和肝素治疗似乎可以根据血栓形成的部位和程度提供良好的结果。我们报告一个5天大的新生儿发生腹主动脉广泛血栓形成的病例，表现为急性高钠性脱水。血栓形成与脐导管插入术无关。诊断证实了多普勒超声发现在病原学评估的一个真实的蛋白S缺乏症。这一观察结果是一个机会，对有关新生儿动脉血栓形成的演变和治疗的临床方面的文献进行审查。
Arterial thrombosis of the newborn is rare and associated with poor prognosis, often attributed to umbilical arterial catheterization. The aortic and spontaneous forms are exceptional. Its severity requires fast and effective treatment. Although therapeutic means are numerous, no consensus has been established to date although thrombolysis and heparin therapy appear to give good results depending on the site and extent of thrombosis. We report a case of extensive thrombosis of the abdominal aorta in a 5-day-old newborn, revealed by acute hypernatremic dehydration. Thrombosis was not related to umbilical catheterization. The diagnosis was confirmed by Doppler ultrasound with discovery during the etiologic assessment of an authentic protein S deficiency. This observation was the occasion for a review of the literature concerning the evolutionary and therapeutic clinical aspects of neonatal arterial thrombosis.