Association of myostatin, a cytokine released by muscle, with inflammation in rheumatoid arthritis: A cross-sectional study.
Association of myostatin, a cytokine released by muscle, with inflammation in rheumatoid arthritis: A cross-sectional study.
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DOI：
10.1097/md.0000000000024186
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发表时间：
2021-01-22
期刊：
影响因子：
1.6
通讯作者：
Gamez-Nava JI
中科院分区：
文献类型：
--
作者：
Murillo-Saich JD;Vazquez-Villegas ML;Ramirez-Villafaña M;Saldaña-Cruz AM;Aceves-Aceves JA;Gonzalez-Lopez L;Guma M;Gamez-Nava JI
补充数字内容可在文本中获得肌生长抑制素是一种细胞因子，由肌细胞产生和释放，不仅在恶病质期间的肌肉萎缩中，而且在炎症中可能具有突出的作用。在此，我们探讨类风湿关节炎（RA）中肌肉生长抑制素水平和炎症参数之间的关系。在一项横断面研究中，对127名无风湿性疾病的妇女和84名诊断为RA的妇女进行了评估。反映关节炎活动性的结果包括疾病活动性评分（DAS 28-ESR）和功能障碍的健康评估量表-残疾指数在RA中进行评估。我们使用双能X线吸收法获得了骨骼肌质量指数（SMI）、去脂质量指数（FFMI）和脂肪质量指数。血清肌生成抑制素测定采用酶联免疫吸附法。肌生长抑制素水平与疾病活动和肌肉质量参数相关。RA患者的SMI低于对照组，而肌生长抑制素浓度高于对照组（分别为P= 0.008和P <0.001）。 肌生长抑制素与C反应蛋白（rho = 0.48，P <0.001）、红细胞沉降率（rho = 0.28，P = 0.009）和DAS 28-ESR（rho = 0.22，P = 0.04）显著正相关，与SMI（rho =-0.29，P = 0.008）、（FFMI）（rho =-0.24，P = 0.027）呈负相关。 在多变量logistic回归分析中，肌生长抑制素水平仍然与RA的疾病活动相关（P = 0.027）。 在我们的研究中，肌生长抑制素与RA患者的疾病活动相关，表明RA中肌生长抑制素、肌肉萎缩和炎症之间存在机械联系。
Supplemental Digital Content is available in the text Myostatin is a cytokine produced and released by myocytes that might have an outstanding role not only in muscle wasting during cachexia but also in inflammation. Herein we explore the association between myostatin levels and inflammatory parameters in rheumatoid arthritis (RA). One hundred twenty-seven women without rheumatic diseases and 84 women with a diagnosis of RA were assessed in a cross-sectional study. Outcomes reflecting the activity of the arthritis including Disease Activity Score (DAS28-ESR) and impairment in functioning by the Health Assessment Questionnaire-Disability Index were assessed in RA. We obtained Skeletal muscle mass index (SMI), fat-free mass index (FFMI), and fat mass index using dual-energy x-ray absorptiometry. Serum myostatin was determined by enzyme-linked immunosorbent assay. Myostatin levels were correlated with disease activity and parameters of muscle mass. The SMI was lower and concentration of myostatin was higher in RA patients than in controls (P = .008 and P < .001, respectively). Myostatin significantly positively correlated with C-reactive protein (rho = 0.48, P < .001), erythrocyte sedimentation rate (rho = 0.28, P = .009), and DAS28-ESR (rho = 0.22, P = .04), and negatively correlated with SMI (rho = −0.29, P = .008), (FFMI) (rho = −0.24, P = .027). In the multivariate logistic regression analysis, levels of myostatin remained associated with disease activity in RA (P = .027). In our study, myostatin was associated with disease activity in RA patients, suggesting a mechanistic link between myostatin, muscle wasting and inflammation in RA.