A PHARMACOKINETIC ANALYSIS PROGRAM (MULTI) FOR MICROCOMPUTER
A PHARMACOKINETIC ANALYSIS PROGRAM (MULTI) FOR MICROCOMPUTER
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DOI：
10.1248/bpb1978.4.879
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
UNO, T
中科院分区：
文献类型：
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作者：
YAMAOKA, K;TANIGAWARA, Y;UNO, T
本文提出了一个微型计算机非线性最小二乘程序（MULTI）。程序用BASIC语言编写。MULTI中的非线性曲线拟合可采用四种算法[高斯-牛顿法、阻尼高斯-牛顿法、修正的马夸特法和单纯形法]。最多5个药代动力学方程，由用户自愿定义，同时拟合观察到的时间进程。MULTI的执行证明了氨苄西林和苯唑西林在人体中的时间过程。
A nonlinear least squares program (MULTI) for microcomputers was developed. The program is written in BASIC programming language. Four algorithms [Gauss-Newton method, damping Gauss-Newton method, modified Marquardt method and simplex method] can be used for nonlinear curve fitting in MULTI. Up to 5 pharmacokinetic equations, voluntarily defined by the user, are simultaneously fitted to observed time courses. The executions of MULTI are demonstrated for time courses of ampicillin and oxacillin in man.