Decreased free sphingoid base concentration in the plasma of patients with chronic systolic heart failure
Decreased free sphingoid base concentration in the plasma of patients with chronic systolic heart failure
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DOI：
10.2478/v10039-011-0057-4
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发表时间：
2012-06-01
影响因子：
2.7
通讯作者：
Musial, W.
中科院分区：
文献类型：
--
作者：
Knapp, M.;Baranowski, M.;Musial, W.
目的：近年来，鞘脂在心脏病理生理学中的作用备受关注。研究发现神经酰胺参与缺血/再灌注损伤、2 型糖尿病和脂毒性心肌病动物模型中心脏功能障碍的发病机制。另一方面，1-磷酸鞘氨醇 (S1P) 已被证明具有有效的心脏保护特性。本研究的目的是检测慢性心力衰竭 (HF) 患者的主要鞘脂血浆浓度。 材料和方法：受试者分为两大组：1) 慢性收缩性心力衰竭 (n=47)，2) 年龄匹配的健康对照者 (n=15)。前一组患者根据心力衰竭的根本原因进一步分组（缺血性心脏病或特发性扩张型心肌病，分别为29例和18例）。结果：两组心力衰竭患者血浆中S1P、1-磷酸二氢鞘氨醇和神经酰胺的浓度与健康对照者的血浆浓度非常接近，未发现统计学上的显着差异。然而，与对照组相比，心力衰竭患者血浆中游离鞘氨醇和二氢鞘氨醇的水平分别降低了25%和27%。这种效应与心力衰竭的根本原因无关，因为缺血性和特发性心力衰竭患者中这些鞘氨醇碱的平均浓度几乎相同。结论：我们得出结论，慢性心力衰竭与血浆中游离鞘氨醇碱浓度降低有关。然而，尽管合成具有心脏保护作用的鞘氨醇碱 1 磷酸盐所需的底物利用率较低，但其血浆水平仍保持稳定。
Purpose: In recent years, the role of sphingolipids in pathophysiology of the heart attracted much attention. Ceramide was found to be involved in the pathogenesis of cardiac dysfunction in animal models of ischemia/reperfusion injury, type 2 diabetes and lipotoxic cardiomyopathy. On the other hand, sphingosine-1-phosphate (S1P), has been shown to possess potent cardioprotective properties. The aim of the present study was to examine plasma concentrations of major sphingolipids in patients with chronic heart failure (HF).Material and Methods: The subjects were divided into two major groups: 1) with chronic systolic HF (n=47), and 2) healthy age-matched controls (n=15). Patients in the former group were further divided according to the underlying cause of HF (ischemic heart disease or idiopathic dilated cardiomyopathy, n=29 and 18, respectively).Results: Plasma concentrations of S1P, sphinganine-1-phosphate and ceramide observed in both groups of HF patients were very close to these noted in the healthy controls, and no statistically significant differences were found. However, the level of free sphingosine and sphinganine in the plasma of patients with HF decreased by 25 and 27%, respectively, as compared to the control subjects. This effect was independent from the underlying cause of HF as the mean concentrations of these sphingoid bases in patients with ischemic and idiopathic HF were virtually the same.Conclusions: We conclude that chronic heart failure is associated with decreased concentration of free sphingoid bases in the plasma. However, despite lower availability of substrates required for synthesis of cardioprotective sphingoid base-1 phosphates, their plasma level remains stable.