Pre-conditioned mesenchymal stem cells: a better way for cell-based therapy.
Pre-conditioned mesenchymal stem cells: a better way for cell-based therapy.
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DOI：
10.1186/scrt213
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发表时间：
2013-06-05
影响因子：
7.5
通讯作者：
Deng Z
中科院分区：
文献类型：
--
作者：
Li Q;Wang Y;Deng Z
缺血性心脏病是全球死亡的主要原因，而最近开发的干细胞移植是治疗心肌梗死的一种有前途的疗法。间充质干细胞（MSC）存在于广泛的组织中，其分化潜能和免疫调节能力使其成为再生医学的最佳候选者。然而，供体细胞在梗死心肌中的存活率低和分化效率低挑战了MSC移植的治疗效果。为此，许多研究人员专注于改善MSC移植前后的微环境，并试图找出其机制。Booathy及其同事最近的一项研究报告了氧化应激对培养的MSC的促心血管分化作用及其潜在的信号通路，从而产生了用氧化试剂预处理的MSC促进MSC的心脏分化效率的概念，并可能对缺血性心脏病产生更好的临床效果。
Ischemic heart disease is the major cause of death globally, and a recently developed stem cell transplantation is a promising therapy for myocardial infarction. Mesenchymal stem cells (MSCs) exist in a wide range of tissues, and their differentiation potential and immunoregulatory capacity make them a more optimal candidate for regenerative medicine. However, the poor survival and low differentiation efficiency of the donor cells in the infarcted myocardium challenged therapeutic efficacy of MSC transplantation. To this end, many researchers have focused on improving the microenvironments of MSCs before and after transplantation and on trying to figure out the mechanisms. A recent study by Boopathy and colleagues reported the pro-cardiovascular differentiation effect of oxidative stress on cultured MSCs and the underlying signal pathways, leading to the notion that MSCs pre-conditioned with oxidative reagents promote cardiac differentiation efficiency of MSCs and may result in better clinical effect for ischemic heart diseases.
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影响因子：
24
作者：
Bartunek, Jozef;Behfar, Atta;Terzic, Andre
通讯作者：
Terzic, Andre
影响因子：
37.8
作者：
Williams AR;Hatzistergos KE;Addicott B;McCall F;Carvalho D;Suncion V;Morales AR;Da Silva J;Sussman MA;Heldman AW;Hare JM
通讯作者：
Hare JM
影响因子：
5.3
作者：
Penna C;Perrelli MG;Karam JP;Angotti C;Muscari C;Montero-Menei CN;Pagliaro P
通讯作者：
Pagliaro P
影响因子：
24
作者：
Behfar, Atta;Yamada, Satsuki;Crespo-Diaz, Ruben;Nesbitt, Jonathan J.;Rowe, Lois A.;Perez-Terzic, Carmen;Gaussin, Vinciane;Homsy, Christian;Bartunek, Jozef;Terzic, Andre
通讯作者：
Terzic, Andre
影响因子：
3.1
作者：
Herrmann, Jeremy L.;Wang, Yue;Meldrum, Daniel R.
通讯作者：
Meldrum, Daniel R.