EFFECTS OF METHYLPHENIDATE ON REPEATED ACQUISITION OF SERIAL DISCRIMINATION REVERSALS
EFFECTS OF METHYLPHENIDATE ON REPEATED ACQUISITION OF SERIAL DISCRIMINATION REVERSALS
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DOI：
10.1007/bf00426967
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发表时间：
1978-01-01
影响因子：
3.4
通讯作者：
CALHOUN, WH
中科院分区：
文献类型：
--
作者：
HANDLEY, GW;CALHOUN, WH
训练大鼠在2种刺激条件中的1种条件下进行蔗糖溶液的棒压。在每天的训练中，压杆强化的刺激被逆转。受试者接受该系列辨别抑制程序的训练，直到辨别力的连续采集稳定下来。然后在每日训练期之前20分钟给予由盐水或0.25、1.0、2.0、4.0、6.0或8.0 mg/kg哌甲酯组成的药物治疗。低剂量哌甲酯（1、2和4 mg/kg）可增强辨别能力，高剂量哌甲酯（6和8 mg/kg）可减弱辨别能力。
Rats were trained to bar-press for sucrose solution in the presence of 1 of 2 stimulus conditions. On each daily training session, the stimulus during which bar-pressing was reinforced was reversed. The subjects were trained in this Serial Discrimination Reversal procedure until successive acquisitions of the discrimination had stabilized. Drug treatments consisting of saline or 0.25, 1.0, 2.0, 4.0, 6.0 or 8.0 mg/kg of methylphenidate were then administered 20 min prior to the daily training sessions. Acquisition of the discrimination was enhanced by low doses of methylphenidate (1, 2 and 4 mg/kg) and attenuated by higher doses (6 and 8 mg/kg).