Destruction and regeneration of skeletal muscle after treatment with a local anaesthetic, bupivacaine (Marcaine).
Destruction and regeneration of skeletal muscle after treatment with a local anaesthetic, bupivacaine (Marcaine).
复制标题
使用局部麻醉剂布比卡因（Marcaine）治疗后骨骼肌的破坏和再生。
作者：
P. Benoit;W. D. Belt
人们早就知道，运动神经供应永久中断后，骨骼肌会发生萎缩（例如 Morpurgo，1892；Ricker 和 Ellenbeck，1899；de Buck 和 de Moor，1903）。伴随着肌浆和肌原纤维物质损失的核变化会持续数月。最终，萎缩的纤维通常会退化并被脂肪组织（Adams、Denny-Brown & Pearson，1962）或纤维组织（Tower，1935）所取代。在四肢的大肌肉中，大多数纤维在 2 个月时会缩小至正常直径的三分之一到二分之一（Adams 等，1962）。已知许多局部麻醉剂在局部注射后会损伤骨骼肌（Brun，1959；Pizzolato & Mannheimer，1961）；另据报道，利多卡因（二乙氨基乙酰-2,6-xylidide）会导致骨骼肌纤维快速破坏，随后受影响区域会再生新纤维（Smith，Feagans，Belt＆Blair，1969）。最近有人声称，当肌肉在几天内多次注射时，长效局部麻醉剂布比卡因 (Marcaine) 能够产生模仿快速去神经萎缩的变化 (Sokoll, Sonesson & Thesleff, 1968; Libelius, Sonesson, Stamenovic & Thesleff, 1970)。该报告涉及大鼠肌肉对布比卡因的反应，并将表明它会导致骨骼肌纤维快速破坏，并随后迅速再生。
It has long been known that skeletal muscle undergoes atrophy following permanent interruption of the motor nerve supply (e.g. Morpurgo, 1892; Ricker & Ellenbeck, 1899; de Buck & de Moor, 1903). Nuclear changes accompanied by loss of sarcoplasm and myofibrillar material continue for months. Ultimately, atrophic fibres usually degenerate and are replaced by fatty tissue (Adams, Denny-Brown & Pearson, 1962) or fibrous tissue (Tower, 1935). In large muscles of the limbs, most fibres are reduced to one-third to one-half of their normal diameters at 2 months (Adams et al. 1962). Many local anaesthetic agents are known to damage skeletal muscle following local injection (Brun, 1959; Pizzolato & Mannheimer, 1961); it has also been reported that lidocaine (diethylaminoacet-2,6-xylidide) causes rapid destruction of skeletal muscle fibres which is followed by regeneration of new fibres in the affected area (Smith, Feagans, Belt & Blair, 1969). Recently it has been claimed that a longacting local anaesthetic, bupivacaine (Marcaine), is capable of producing changes which mimic a rapid denervation atrophy when the muscle is exposed to multiple injections over several days' duration (Sokoll, Sonesson & Thesleff, 1968; Libelius, Sonesson, Stamenovic & Thesleff, 1970). This report concerns itself with the response to bupivacaine of muscle in the rat and will show that it causes a rapid destruction of fibres of skeletal muscle and that a rapid regeneration follows.