Acute effect of oral phosphate loading on serum fibroblast growth factor 23 levels in healthy men
Acute effect of oral phosphate loading on serum fibroblast growth factor 23 levels in healthy men
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DOI：
10.1038/sj.ki.5002000
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发表时间：
2006-12-01
影响因子：
19.6
通讯作者：
Takeda, E.
中科院分区：
文献类型：
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作者：
Nishida, Y.;Taketani, Y.;Takeda, E.
血清成纤维细胞生长因子 23 (FGF23) 是一种新型磷酸盐因子，对于调节无机磷酸盐 (Pi) 稳态非常重要。在这项研究中，我们检查了口服 Pi 负荷对血清 FGF23 水平的急性影响，以阐明快速调节血清 Pi 水平的作用。我们对八名健康男性志愿者进行了一项随机、双盲、交叉研究。中午，受试者轮流享用含有不同 Pi 含量（400 mg (P400)、800 mg (P800) 和 1200 mg (P1200)）的三顿测试餐中的一份作为午餐。估计Pi、Ca、1,25-二羟基维生素D、完整甲状旁腺激素（iPTH）、完整FGF23（iFGF23）的餐后血清水平变化，以及Pi负荷后8小时之前Pi和Ca的尿排泄。摄入 P400 和 P800 后 1 小时内，血清 Pi 水平和尿 Pi 排泄量显着增加。摄入P1200后1-2小时和4-6小时血清iPTH水平显着高于摄入P400的血清iPTH水平。血清 iFGF23 水平在 P400 摄入后 8 小时内和 P800 摄入后 6 小时内略有下降，但在 P1200 摄入后没有变化。与 P400 和 P800 摄入相比，摄入 P1200 后 8 小时观察到 iFGF23 显着增加。此外，在短期内检测到 iFGF23 与血清 Pi 之间呈负相关，而 iPTH 与血清 Pi 之间呈正相关。我们的结论是口服Pi负荷不能快速增加血清FGF23水平。 FGF23 可能与 Pi 稳态的快速适应无关。
Serum fibroblast growth factor 23 (FGF23) is a novel phosphaturic factor and important for the regulation of inorganic phosphate ( Pi) homeostasis. In this study, we examined an acute effect of oral Pi loading on serum FGF23 levels to clarify the role in rapid adjustment of serum Pi level. We performed a randomized, double-blind, crossover study in eight healthy male volunteers. The subjects were alternately served one of three test meals containing different Pi amounts (400 mg (P400), 800mg (P800), and 1200mg (P1200)) as lunch at noon. The postprandial changes in serum levels of Pi, Ca, 1,25-dihydroxyvitamin D, intact-parathyroid hormone (iPTH), intact-FGF23 (iFGF23), and urinary excretion of Pi and Ca until 8 h after Pi loading were estimated. Serum Pi levels and urinary Pi excretion significantly increased within 1 h after P400 and P800 intake. Serum iPTH levels at 1-2 and 4-6 h after P1200 intake was significantly higher than those of P400 intake. Serum iFGF23 levels slightly decreased up to 8 h after P400 intake and up to 6 h after P800 intake, but not changed in P1200 intake. Significant increase of iFGF23 was observed at 8 h after P1200 intake compared with both P400 and P800 intake. Additionally, negative association was detected between iFGF23 and serum Pi, whereas positive association was observed between iPTH and serum Pi during the short period. We conclude that oral Pi loading cannot rapidly increase serum FGF23 level. FGF23 may be not associated with rapid adaptation of Pi homeostasis.