Hidden cytoplasmic incompatibility alters the dynamics of male-killer/host interactions
Hidden cytoplasmic incompatibility alters the dynamics of male-killer/host interactions
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DOI：
10.1111/j.1420-9101.2009.01872.x
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发表时间：
2010-03-01
影响因子：
2.1
通讯作者：
Hurst, G. D. D.
中科院分区：
文献类型：
--
作者：
Hornett, E. A.;Engelstaedter, J.;Hurst, G. D. D.
沃尔巴克氏体以多种方式操纵节肢动物宿主的繁殖。最近的研究表明，这些细菌可能会结合联合收割机的表型-拥有一个“雄性杀伤”的表型，并在男性生存，诱导细胞质不相容性（CI）。我们在这里开发了一个数学模型，以调查在何种程度上“隐藏”CI可能会影响宿主基因的进化动力学，抑制雄性杀伤活性。我们观察到，对于高流行率感染，CI驱使抑制因子和细菌两者达到更高的频率，使得菌株似乎仅表现出CI。相比之下，对于低流行率感染，CI阻碍抑制基因的侵入，因为存活的感染男性与人口中的大多数女性不相容。我们的研究结果表明，“隐藏”的表型以及可观察到的相互作用的动力学的影响，这些知识，因此需要预测何时抑制基因将入侵，其入侵的后果。
Wolbachia manipulate the reproduction of their arthropod hosts in a variety of ways. Recent work has demonstrated that these bacteria may combine phenotypes - possessing a 'male killing' phenotype and, where males survive, induce cytoplasmic incompatibility (CI). We here develop a mathematical model to investigate the extent to which 'hidden' CI may affect the evolutionary dynamics of host genes that suppress male-killing activity. We observed that for high prevalence infections, CI drives both suppressor and bacterium to higher frequency, such that the strain appears to solely exhibit CI. In contrast, for low prevalence infections, CI impedes suppressor invasion as surviving infected males are incompatible with the majority of females in the population. Our results demonstrate that 'hidden' phenotypes as well as observable ones can impact on the dynamics of the interaction, and knowledge of these is therefore required to predict when suppressor genes will invade, and the consequences of their invasion.