Karyotypic rearrangements in 20 uterine leiomyomas.
Karyotypic rearrangements in 20 uterine leiomyomas.
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20 例子宫肌瘤的核型重排。
DOI：
10.1159/000132682
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
F. Mitelman
中科院分区：
文献类型：
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作者：
M. Nilbert;S. Heim;N. Mandahl;U. Flodérus;H. Willén;F. Mitelman
本文对106例子宫平滑肌瘤的短期培养进行了细胞遗传学研究。29例中期数量不足，无法进行分析。正常女性核型57例，克隆性染色体重排20例。在10个肿瘤中观察到反向易位t(12;14) (q14----q15;q23----q24)，这可能代表了致瘤性的主要变化。在包含这种特殊异常的4个肿瘤中，也存在次级染色体改变。10例核型不含t的异常平滑肌瘤（12;14）存在各种结构和数值畸变，涉及染色体1、2、3、4、6、8、9、10、11、12、13和19。第1号染色体的不同结构变化是第二常见的异常，在五种肿瘤中都有发现。环状染色体在三种情况下被观察到，但从来没有作为唯一的变化。
Short-term cultures from 106 uterine leiomyomas have been cytogenetically investigated. In 29 cases the number of metaphases was insufficient for analysis. A normal female karyotype was found in 57 tumors and clonal chromosome rearrangements in 20. A reciprocal translocation, t(12;14) (q14----q15;q23----q24), was observed in 10 tumors and probably represents a primary change of tumorigenic importance. In four of the tumors containing this specific anomaly, secondary chromosome changes were also present. The 10 karyotypically abnormal leiomyomas without a t(12;14) had various structural and numerical aberrations involving chromosomes 1, 2, 3, 4, 6, 8, 9, 10, 11, 12, 13, and 19. Different structural changes of chromosome 1 were the second most frequent abnormalities, being found in five tumors. Ring chromosomes were observed in three cases, but never as the sole change.