Effect of SMB-gel on peridural adhension after laminectomy
Effect of SMB-gel on peridural adhension after laminectomy
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发表时间：
2006
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通讯作者：
Yang Hong-tu
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作者：
Yang Hong-tu
目的探讨预防椎板切除术后硬膜外粘连的有效材料和方法。方法从卡波姆和丹参中分别获得凝胶剂和丹参凝胶剂。将36只家兔随机分为4组，分别行L3、L 6椎板切除术，造成10 mm×5 mm椎板缺损。A组为空白对照组，B组为治疗组，C组为2%透明质酸钠治疗组，D组为SMB凝胶治疗组。术后4周每组取1例标本行透射电镜检查。术后第4、6、8周对各组硬膜外粘连情况进行计算机图像分析。结果A、B、C组与D组在各时间点的粘连厚度差异有统计学意义，F值分别为128.657、152.246、80.891。术后4周，A、B、C组可见增生的成纤维细胞，D组未见增生。结论SMB-gel预防椎板切除术后硬膜外粘连效果最好。SMB可抑制成纤维细胞增殖。
Objective To find out the effective materials and methods for the prevention of peridural adhension after laminectomy. Methods The gel and salviamiltriorrhiza (SMB)-gel were acquired from the Carbomer and SMB. Laminectomy was performed in L3, L6 on 36 rabbits which had been divided into 4 groups randomly, and resulted in the status of 10 mm×5 mm lamina defect. Different treatments were applied on the 4 groups:group A (blank control), group B (get treated), group C (2% sodium hyaluronate treated), and group D (SMB-gel treated). One specimen of each group was examined under electron transmission microscopy at the 4th postoperative week. Computed imaging analysis of epidural adhension of each group was also done at the 4th, 6th, and 8th postoperative week. Results At each time, there was statistical difference in the thickness of the adhension between group A, B, C and group D with F values being 128.657,152.246,80.891 respectively. The proliferating fibroblasts could be observed by microscopy at 4th postoperative week in groups A, B and C, while in group D, the proliferation was inactive. Conclusion SMB-gel has been proved to have the best effect in preventing peridural adhesion after laminectomy. SMB can inhibit the fibroblasts from proliferation.