Factor analysis of medical image sequences in MR of head and neck tumors.
Factor analysis of medical image sequences in MR of head and neck tumors.
复制标题
头颈肿瘤 MR 医学图像序列的因子分析。
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
R. Di Paola
中科院分区：
文献类型：
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作者：
A. Zagdanski;R. Sigal;J. Bosq;J. Bazin;D. Vanel;R. Di Paola
目的
为了评价医学图像序列的因子分析（FAMIS），一种在采集动态MR图像后估计生理对比度增强动力学（称为因子）及其空间分布（称为因子图像）的方法。该方法旨在自动识别和表征不同的组织动力学。
方法
在22例头颈部肿瘤患者中对该方法进行了评价。11例患者出现既往未经治疗的病变。六人接受了肿瘤复发检查，以前接受过多种治疗。5例患者术前化疗，化疗前后均行MR检查。所有病例的MR图像均与手术和病理资料相对照。MR检查在1.5-T设备上进行，静态序列和动态序列在团注钆后获得，并由FAMIS处理。
结果
FAMIS能够识别代表对比增强动力学的三个因素及其相关因素图像。肿瘤成分与早期因子图像F1相关。纤维化和化疗和/或放射诱导的变化与后两个因素F2和F3相关。这种方法的局限性是高度血管化的组织，其早期因素与肿瘤组织（粘膜和唾液腺）相似，患者运动，导致FAMIS中的伪影，以及小于5 mm的病变。
结论
动态MR研究的FAMIS可用于区分肿瘤组织与化疗和/或放疗后发生变化的组织，但它不能提高MR表征既往未治疗患者肿瘤组织的能力。
PURPOSE
To evaluate factor analysis of medical image sequences (FAMIS), a means whereby physiologic contrast enhancement kinetics, called factors, and their spatial distribution, termed factor images, are estimated after acquisition of dynamic MR images. The method is intended to recognize and characterize the different tissue kinetics automatically.
METHODS
This method was evaluated in a series of 22 patients with head and neck tumors. Eleven patients presented with a previously untreated lesion. Six were examined for tumor recurrence, previously treated by multiple therapies. Five patients had preoperative chemotherapy and underwent MR before and after chemotherapy. In all cases, MR images were correlated with surgical and pathologic data. MR examinations were performed on a 1.5-T unit with static sequences and dynamic sequences acquired after bolus injection of gadolinium and processed by FAMIS.
RESULTS
FAMIS was able to identify three factors representing contrast-enhancement kinetics and their associated factor images. The neoplastic component was associated with the earlier factor image, F1. Fibrosis and chemotherapy and/or radiation-induced changes were associated with the two later factors, F2 and F3. The limits of this method were highly vascularized tissues whose earlier factor was similar to that of neoplastic tissues (mucosae and salivary glands), patient motion, responsible for artifacts in FAMIS, and lesions of less than 5 mm.
CONCLUSION
FAMIS of dynamic MR studies was useful for differentiating neoplastic tissue from tissue having undergone changes by chemotherapy and/or radiotherapy, but it did not improve the ability of MR to characterize neoplastic tissues in previously untreated patients.