Association between adherence to the Mediterranean diet and oxidative stress
Association between adherence to the Mediterranean diet and oxidative stress
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DOI：
10.3945/ajcn.2008.26528
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发表时间：
2008-11-01
影响因子：
7.1
通讯作者：
Vaccarino, Viola
中科院分区：
文献类型：
--
作者：
Dai, Jun;Jones, Dean P.;Vaccarino, Viola
背景：地中海饮食的心脏保护特性归因于其抗氧化能力，但对这一机制的直接研究有限。目的：在一项对照良好的双胞胎研究中，我们研究了地中海饮食与氧化应激血浆标志物还原性谷胱甘肽（GSH/GSSG）之间的关系。设计：我们对138对同卵双胞胎和异卵双胞胎以及21对未配对双胞胎进行了Willett食物频率问卷调查，并得出了衡量地中海饮食依从性的评分。测定空腹血浆GSH和GSSG浓度，计算GSH/GSSG比值。比值越高，氧化应激越低。使用混合效应回归分析将关联划分为双胞胎间差异和双胞胎内差异。当检查双内效应时，双胞胎在社会人口统计学和家庭因素方面是匹配的。结果：在调整了能量摄入、其他营养因素、心血管疾病危险因素和药物使用后，饮食评分每增加一个单位，GSH/GSSG比值增加7% （P = 0.03）。这种关联在双胞胎中仍然存在：饮食评分中一个单位的绝对差值与得分较高的双胞胎中GSH/GSSG比值比得分较低的双胞胎高10% （95% CI: 2.7, 18.0）相关（P = 0.007）。结果在同卵双胞胎和异卵双胞胎中相似。结论：地中海饮食和血浆氧化应激之间的关联是强大的，不受遗传或共同环境因素的干扰。减少氧化应激是一种将地中海饮食与降低心血管疾病风险联系起来的合理机制。J·克林·努尔2008；88: 1364 - 70。
Background: The cardioprotective property of the Mediterranean diet has been attributed to its antioxidant capacity, but direct investigation of this mechanism has been limited.Objective: We examined the association between the Mediterranean diet and an established plasma marker of oxidative stress, the ratio of reduced to oxidized glutathione (GSH/GSSG), in a well-controlled study of twins.Design: We administered the Willett food-frequency questionnaire to 138 monozygotic and dizygotic twin pairs and to 21 unpaired twins and derived a score measuring adherence to the Mediterranean diet. Fasting plasma GSH and GSSG concentrations were measured to calculate the GSH/GSSG ratio. The higher the ratio, the lower the oxidative stress. Mixed-effect regression analysis was used to partition the association into between-and within-twin pair differences. When within-pair effects are examined, twins are matched for sociodemographic and familial factors.Results: A one-unit increment in the diet score was associated with a 7% higher GSH/GSSG ratio (P = 0.03) after adjustment for energy intake, other nutritional factors, cardiovascular disease risk factors, and medication use. The association persisted within twin pairs: a one-unit within-pair absolute difference in the diet score was associated with a 10% (95% CI: 2.7, 18.0) higher GSH/GSSG ratio in the twin with the higher score than in the co-twin with the lower score (P = 0.007). Results were similar in monozygotic and dizygotic twin pairs.Conclusions: The association between the Mediterranean diet and plasma oxidative stress is robust and is not confounded by genetic or shared environmental factors. Decreased oxidative stress is a plausible mechanism linking the Mediterranean diet to reduced cardiovascular disease risk. Am J Clin Nutr 2008; 88: 1364-70.